Recruitment and treatment practices for help-seeking "prodromal" patients
Recruitment and treatment practices for help-seeking "prodromal" patients
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DOI：
10.1093/schbul/sbm025
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发表时间：
2007-05-01
影响因子：
6.6
通讯作者：
Yung, Alison
中科院分区：
文献类型：
--
作者：
McGlashan, Thomas H.;Addington, Jean;Yung, Alison
精神病的前驱期已成为早期识别以及针对症状和未来患精神病风险进行治疗的目标。这一领域的关注和活动现已遍及全球。采用严谨方法的临床试验才刚刚开始，制定治疗指南还为时过早。尽管证据基础薄弱，但目前在前驱期新诊所中，已对患者进行治疗，这些治疗通常是针对已确诊的精神病而研发，并针对前驱期进行了调整。本文将介绍在全球前驱期诊所中，目前如何招募寻求治疗的前驱期患者以及对其进行治疗的代表性案例。招募包括如何寻找前驱期患者、对其进行初步评估、告知他们处于高风险状态、介绍前驱期治疗的风险和益处以及如何长期监测他们的精神状态。所提供（并描述）的治疗方式包括参与、支持性治疗、病例管理、压力管理、认知行为治疗、基于家庭的治疗、抗精神病药物治疗以及非抗精神病药物治疗。文中注明了详细参考资料。
The prodrome of psychosis has become a target for early identification and for treatments that address both symptoms and risk for future psychosis. Interest and activity in this realm is now worldwide. Clinical trials with rigorous methodology have only just begun, making treatment guidelines premature. Despite the sparse evidence base, treatments are currently applied to patients in the new prodromal clinics, usually treatments developed for established psychosis and modified for the prodromal phase. This communication will describe representative samplings of how treatment-seeking prodromal patients are currently recruited and treated in prodromal clinics worldwide. Recruitment includes how prodromal patients are sought, initially evaluated, apprised of their high-risk status, and informed of the risks and benefits of prodromal treatments and how their mental state is monitored over time. The treatment modalities offered (and described) include engagement, supportive therapy, case management, stress management, cognitive behavioral treatment, family-based treatment, antipsychotic pharmacotherapy, and non-antipsychotic pharmacotherapy. References for details are noted.