A review of cognitive impairment and cerebral metabolite abnormalities in patients with hepatitis C infection
A review of cognitive impairment and cerebral metabolite abnormalities in patients with hepatitis C infection
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DOI：
10.1097/01.aids.0000192071.72948.77
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发表时间：
2005-10-01
期刊：
影响因子：
3.8
通讯作者：
Taylor-Robinson, SD
中科院分区：
文献类型：
--
作者：
Forton, DA;Allsop, JA;Taylor-Robinson, SD
许多研究报告了慢性丙型肝炎病毒（HCV）感染与疲劳，抑郁和健康相关生活质量受损之间的相关性，这些与肝脏疾病的严重程度无关。虽然这些症状有大量的潜在解释，包括药物滥用史和相关的人格类型，或诊断HCV感染本身的影响，但最近人们对HCV感染对脑功能的生物学影响的可能性感兴趣。有新的证据表明，轻度，但显着的神经认知功能障碍的丙型肝炎病毒感染，这不能完全归因于药物滥用，共存的抑郁症或肝性脑病。损伤主要在注意力、集中力和信息处理速度方面。此外，在丙型肝炎和肝功能正常的患者体内脑磁共振波谱研究报告了脑含胆碱化合物的升高和N-乙酰天冬氨酸的减少，这表明生物学机制可能是认知结果的基础。最近在死后脑组织中检测到HCV基因序列提出了一种有趣的可能性，即中枢神经系统的HCV感染可能与所报道的神经心理学症状和认知障碍有关。(c)2005年，利平科特·威廉斯和威尔金斯。
Numerous studies have reported associations between chronic hepatitis C virus (HCV) infection and fatigue, depression and impairments in health-related quality of life, which are independent of the severity of liver disease. Although there are a large number of potential explanations for these symptoms, including a history of substance abuse and associated personality types, or the effect of the diagnosis of HCV infection itself, there has been recent interest in the possibility of a biological effect of HCV infection on cerebral function. There is emerging evidence of mild, but significant neurocognitive impairment in HCV infection, which cannot be wholly attributed to substance abuse, co-existent depression or hepatic encephalopathy. Impairments are predominantly in the domains of attention, concentration and information processing speed. Furthermore, in-vivo cerebral magnetic resonance spectroscopy studies in patients with hepatitis C and normal liver function have reported elevations in cerebral choline-containing compounds and reductions in N-acetyl aspartate, suggesting that a biological mechanism may underlie the cognitive findings. The recent detection of HCV genetic sequences in post-mortem brain tissue raises the intriguing possibility that HCV infection of the central nervous system may be related to the reported neuropsychological symptoms and cognitive impairment. (c) 2005 Lippincott Williarns & Wilkins.