Cutting edge:: Organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-α (LTα) and retinoic acid receptor-related orphan receptor-γ, but the organization of NALT is LTα dependent
Cutting edge:: Organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-α (LTα) and retinoic acid receptor-related orphan receptor-γ, but the organization of NALT is LTα dependent
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DOI：
10.4049/jimmunol.168.3.986
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发表时间：
2002-02-01
影响因子：
4.4
通讯作者：
Randall, TD
中科院分区：
文献类型：
--
作者：
Harmsen, A;Kusser, K;Randall, TD
Peyer氏斑和鼻相关淋巴组织(NALT)是结构和功能相似的粘膜淋巴组织。令人惊讶的是，我们发现，与Peyer氏斑不同，NALT是独立于淋巴毒素(LT)α形成的。此外，使用缺乏维甲酸受体相关的孤儿受体-伽马的小鼠，我们发现NALT是在没有CD4(+)CD3(-)细胞的情况下形成的，这些细胞被认为是LTalpha的胚胎来源。然而，我们也发现LTalpha(-/-)动物的NALT是无序的和淋巴细胞减少的，这表明NALT中淋巴细胞的组织和招募仍然依赖于LTalpha。最后，我们证明了LTalpha(-/-)动物在与正常骨髓重建后，NALT的结构和功能都得到了恢复。这些结果表明，NALT的器官发生是通过独特的机制发生的。
Peyer's patch and nasal-associated lymphoid tissue (NALT) are mucosal lymphoid tissues that appear similar in structure and function. Surprisingly, we found that NALT, unlike Peyer's patch, was formed independently of lymphotoxin (LT)alpha. Furthermore, using mice deficient in the retinoic acid receptor-related orphan receptor-gamma, we found that NALT was formed in the absence of CD4(+)CD3(-) cells, which are thought to be the embryonic source of LTalpha. However, we also found that NALT of LTalpha(-/-) animals was disorganized and lymphopenic, suggesting that the organization and recruitment of lymphocytes within NALT remained dependent on LTalpha. Finally, we demonstrated that both the structure and function of NALT were restored in LTalpha(-/-) animals upon reconstitution with normal bone marrow. These results demonstrate that the organogenesis of NALT occurs through unique mechanisms.