Antidepressant effects of ketamine in depressed patients
Antidepressant effects of ketamine in depressed patients
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DOI：
10.1016/s0006-3223(99)00230-9
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发表时间：
2000-02-15
影响因子：
10.6
通讯作者：
Krystal, JH
中科院分区：
文献类型：
--
作者：
Berman, RM;Cappiello, A;Krystal, JH
背景：越来越多的临床前研究表明，大脑谷氨酸系统可能参与了抑郁症的病理生理过程和抗抑郁药物的作用机制。这是第一个评估单剂量N-甲基-D-天冬氨酸(NMDA)受体拮抗剂治疗抑郁症疗效的安慰剂对照双盲试验。方法：7名重度抑郁症患者在随机、双盲条件下完成2个休息日，包括静脉注射盐酸氯胺酮(0.5 mg/kg)或生理盐水。结果：抑郁症患者在输注氯胺酮后72小时内抑郁症状明显改善(即，，平均25项汉密尔顿抑郁量表评分在积极治疗和假治疗期间分别下降了14+/-SD 10分和0+/-12分)。结论：这些结果提示NMDA受体调节药物在抑郁症治疗中的潜在作用。生物精神病学2000；47：351-354(C)2000生物精神病学学会。
Background: A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology, of major depression and the mechanism of action of antidepressants, This is the first placebo-controlled double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate (NMDA) receptor antagonist in patients with depression,Methods: Seven subjects with major depression completed 2 rest days that involved intravenous treatment with ketamine hydrochloride (.5 mg/kg) or saline solutions under randomized, double-blind conditions.Results: Subjects with depression evidenced significant improvement in depressive symptoms within 72 hours after ketamine but not placebo infusion (i.e,, mean 25-item Hamilton Depression Rating Scale scores decreased by 14 +/- SD 10 points vs. 0 +/- 12 points, respectively during active and sham treatment).Conclusions: These results suggest a potential role for NMDA receptor-modulating drugs in the treatment of depression. Biol Psychiatry 2000;47:351-354 (C) 2000 Society of Biological Psychiatry.