Racial aspects of comorbidity in systemic lupus erythematosus.
Racial aspects of comorbidity in systemic lupus erythematosus.
复制标题
系统性红斑狼疮合并症的种族方面。
DOI：
10.1002/art.1790090613
复制
发表时间：
1996
期刊：
影响因子：
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通讯作者：
Rothfield,NF
中科院分区：
文献类型：
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作者：
Walsh,SJ;Algert,C;Rothfield,NF
目标。通过比较系统性红斑狼疮（SLE）患者死亡时的合并症，研究SLE表达的种族差异。方法：对1989-1991年美国白人和黑人女性中常见致死原因的比例死亡率进行估计，这些女性的死亡证明将SLE列为潜在或致病原因。采用Logistic回归分析来评估SLE和种族对比例死亡率变化的影响，以非SLE死亡率作为比较基线。结果：SLE常见的导致死亡的原因包括已知的疾病后遗症。这些疾病的比例死亡率因种族和年龄而异。然而，在列出SLE的黑人死亡中，肾脏疾病的发生率超过了所有其他疾病的发生率，与年龄无关。当任何年龄组的黑人SLE死亡或白人SLE死亡中肾脏疾病的发生率与白人非SLE死亡的发生率进行比较时，比例死亡率显著大于1。当黑人非系统性红斑狼疮死亡率与白人非系统性红斑狼疮死亡率进行比较时，这一结论也成立。然而，在所有年龄段，黑人SLE死亡中肾脏疾病的比例死亡率显著高于白人SLE死亡和黑人非SLE死亡的相应比例。结论：死于SLE的黑人女性似乎经历了SLE患者和所有黑人报告的过度肾脏疾病的组合。这种组合可能是美国黑人SLE死亡率升高的原因之一。
Objective.To investigate racial differences in the expression of systemic lupus erythematosus (SLE) by comparing comorbidity at death among individuals with SLE.Methods.Proportional mortality rates were estimated for common contributing causes of death among white and black females in the United States, 1989–1991, whose death certificates listed SLE as an underlying or contributing cause. Logistic regression analysis was used to assess the effects of SLE and race on variation in proportional mortality using rates from non SLE deaths as a comparison baseline.Results.Common contributing causes of death listed with SLE included conditions that are known sequelae of the disease. Proportional mortality rates for these conditions varied with race and age. However, among black deaths that listed SLE, the rates of renal disease surpassed those of all other conditions regardless of age. When rates of renal disease among black SLE deaths or among white SLE deaths in any age group were compared to those among white non‐SLE deaths, proportional mortality ratios were significantly greater than 1. This also held when rates of renal disease among black non‐SLE deaths were compared to rates among white non‐SLE deaths. However, across all ages, the proportional mortality ratios for renal disease in black SLE deaths significantly exceeded corresponding ratios for white SLE deaths and for black non‐SLE deaths.Conclusion.Black females who die with SLE appear to experience a combination of the excess renal disease reported for persons with SLE and for all blacks. This combination may be a source of the elevated SLE mortality rates observed among US blacks.