INFLUENCE OF CHRONIC DEEP BRAIN-STIMULATION ON EXCITABILITY AND MORPHOLOGY OF THE STIMULATED TISSUE
INFLUENCE OF CHRONIC DEEP BRAIN-STIMULATION ON EXCITABILITY AND MORPHOLOGY OF THE STIMULATED TISSUE
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DOI：
10.1007/bf01404668
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发表时间：
1979-01-01
影响因子：
2.4
通讯作者：
SCHLOR, KH
中科院分区：
文献类型：
--
作者：
STOCK, G;STURM, V;SCHLOR, KH
通过长期植入玻璃绝缘不锈钢电极，对清醒的自由猫进行不同间隔的双极电刺激，刺激头侧海马区和杏仁核。在6个月至1年半的研究期间，刺激组织的兴奋性保持不变，这是通过定期比较由吻侧海马电刺激引起的诱发电位的形状、潜伏期和幅度，并记录在同侧乳头体内所揭示的。刺激组织的组织学检查显示，由于电极插入造成的创伤，纤维状胶质细胞增多，但由于电刺激或慢性机械刺激，没有额外的组织损伤迹象。结果表明，治疗性刺激脑深部结构的可能性较长，而不会引起刺激组织的形态或电反应的相关变化。如果以不规则的间隔进行刺激，则不会出现点燃现象。
Bipolar electrical rostral hippocampus and amygdala stimulations were performed at irregular intervals on wakeful unrestrained cats via chronically implanted glass-insulated stainless steel electrodes. Stimulated tissue excitability remained unchanged during the 6 mo.-1 1/2 yr investigation period, as revealed by regularly performed comparisons of shape, latency, and amplitude of evoked potentials elicited by electrical rostral hippocampus stimulation and recorded within the ipsilateral mammillary body. Histological examination of stimulated tissue revealed fibrillary gliosis due to trauma caused by the electrode insertion but no additional tissue damage signs due to electrical stimulation or chronic mechanical irritation. The results indicate the possibility of therapeuticly stimulating deep brain structures for long periods without inducing relevant changes in morphology or electrical responsiveness of stimulated tissue. There are no kindling phenomena if stimulations are performed at irregular intervals.