Differentially Degradable Janus Particles for Controlled Release Applications
Differentially Degradable Janus Particles for Controlled Release Applications
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DOI：
10.1002/marc.201200054
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发表时间：
2012-07-26
影响因子：
4.6
通讯作者：
Lahann, Joerg
中科院分区：
文献类型：
--
作者：
Hwang, Sangyeul;Lahann, Joerg
通过电流体动力学（EHD）共喷射和随后的受控交联制备具有差异降解隔室的Janus颗粒。这些双室颗粒由一个半球中的聚（环氧乙烷）和聚（丙烯酰胺-共-丙烯酸）的互穿聚合物网络和第二室中的葡聚糖和聚（丙烯酰胺-共-丙烯酸）链段的交联共聚物组成。组成各向异性导致不同的水解敏感性：虽然两个隔室在pH 3.0下稳定，但在5天内观察到含PEO隔室pH 7.4的选择性降解。具有差异可降解聚合物隔室的Janus颗粒可能对一系列口服药物递送应用感兴趣，因为它们具有解耦释放曲线的倾向。
Janus particles with differentially degradable compartments were prepared by electrohydrodynamic (EHD) co-jetting and subsequent controlled crosslinking. These bicompartmental particles are composed of an interpenetrating polymer network of poly(ethylene oxide) and poly(acrylamide-co-acrylic acid) in one hemisphere and a crosslinked copolymer of dextran and poly(acrylamide-co-acrylic acid) segments in the second compartment. The compositional anisotropy caused differential hydrolytic susceptibility: Although both compartments were stable at pH 3.0, selective degradation of the PEO-containing compartment pH 7.4 was observed wtihin 5 days. Janus particles with differentially degradable polymer compartments may be of interest for a range of oral drug delivery applications because of their propensity for decoupled release profiles.