Experimental Validation of Perfusion Imaging With HOSVD Clutter Filters.
Experimental Validation of Perfusion Imaging With HOSVD Clutter Filters.
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DOI：
10.1109/tuffc.2020.2989109
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发表时间：
2020-09
期刊：
影响因子：
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通讯作者：
Insana MF
中科院分区：
文献类型：
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作者：
Zhu Y;Kim M;Hoerig C;Insana MF
使用透析盒作为灌注模体，验证了用于血流灌注成像的新型脉冲多普勒方法。在体内，在24 MHz下定性证明的技术，在5 MHz和12.5 MHz下，使用模拟血液的体模和纤维素微纤维内的流体流动进行了定量检查。一个目标是探索各种流动状态，以优化测量灵敏度和流动精度。结果表明，以大约10帧/S的速度采集2-3次S回波，对流量的敏感性最高，为1-4毫升/分钟。第二个目标是研究设置高阶奇异值分解(HOSVD)杂波滤波器参数的方法。对于静止或运动的杂波，微纤维中模拟血液的液体的速度在测量不确定度内一致地估计(平均变异系数=0.26)。功率多普勒信号经杂波滤波后等效于静止杂波和运动杂波，当0≤Q≤为4m L/m in时，仿血液体流量每m L/m in增加约3d B。体模和临床前图像的比较表明，在没有对比度增强的情况下，外围灌注成像可以可靠地实现。
Novel pulsed-Doppler methods for perfusion imaging are validated using dialysis cartridges as perfusion phantoms. Techniques that were demonstrated qualitatively at 24 MHz, in vivo, are here examined quantitatively at 5 and 12.5 MHz using phantoms with blood-mimicking fluid flow within cellulose microfibers. One goal is to explore a variety of flow states to optimize measurement sensitivity and flow accuracy. The results show that 2–3 s echo acquisitions at roughly 10 frames/s yields the highest sensitivity to flows 1–4 mL/min. A second goal is to examine methods for setting the parameters of higher-order singular value decomposition (HOSVD) clutter filters. For stationary or moving clutter, the velocity of blood-mimicking fluid in the microfibers is consistently estimated within measurement uncertainty (mean coeff of variation = 0.26). Power Doppler signals were equivalent for stationary and moving clutter after clutter filtering, increasing approximately 3 dB per mL/min of blood-mimicking fluid flow for 0≤ q ≤4 mL/min. Comparisons between phantom and preclinical images show that peripheral perfusion imaging can be reliably achieved without contrast enhancement.