MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis
MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis
复制标题
DOI：
10.1631/jzus.b1500236
复制
发表时间：
2016-05-01
影响因子：
5.1
通讯作者：
Wang, Yong
中科院分区：
文献类型：
--
作者：
Xie, Qiu-ping;Xiang, Cheng;Wang, Yong
在各种研究中，结肠癌转移相关蛋白1（MACC 1）在人肺癌、结肠癌和肝细胞癌中异常高表达。我们的研究集中在MACC1表达与胃癌（GC）的关联。在我们的实验中，MACC1的表达进行了测试，在105 GC样品使用免疫组织化学（IHC）方法。总结其临床特点及预后。在分析过程中，MACC1在有远处转移的GC样品中的分布高于正常样品和无扩散的肿瘤。随后，较低的5年生存率与高MACC1表达有很强的相关性。因此，本研究结果表明，MACC1更频繁地表达在胃癌的预后不良表型，并作为一个有前途的预后预测参数胃癌。
In various studies, metastasis associated with colon cancer 1 (MACC1) has been frequently reported to be abnormally highly expressed in human lung cancer, colon cancer, and hepatocellular carcinoma. Our study focuses on the association of MACC1 expression with gastric cancer (GC). During our experiment, the MACC1 expression was tested in 105 GC samples using an immunohistochemical (IHC) method. The clinical characteristics and prognosis of these patients were summarized. During analysis, MACC1 distribution in GC samples with distant metastasis was higher than that in normal samples and in tumors with no dissemination. Subsequently, a lower 5-year survival rate had a strong correlation with high MACC1 expression. As a consequence, the present results suggest that MACC1 is more frequently expressed in a poor prognosis phenotype of GC and acts as a promising prognostic prediction parameter for GC.