HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation.
HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation.
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DOI：
10.3390/ijms22115506
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发表时间：
2021-05-23
影响因子：
5.6
通讯作者：
Kim KT
中科院分区：
文献类型：
--
作者：
Ryu HG;Jung Y;Lee N;Seo JY;Kim SW;Lee KH;Kim DY;Kim KT
异质核核糖核蛋白（HNRNP）A1是HNRNP蛋白家族中最丰富和广泛表达的成员。近年来，越来越明显的是，HNRNP A1有助于神经退行性疾病的发展。然而，关于HNRNP A1在癌症发展中的潜在作用知之甚少。在这里，我们报告说，HNRNP A1的表达显着增加，在肺癌组织中，与肺癌患者的总生存率呈负相关。此外，HNRNP A1通过直接与VRK1 mRNA的3′非翻译区（UTR）结合，积极调节牛痘相关激酶1（VRK1）的翻译，从而通过VRK1介导的cAMP反应元件结合蛋白（CREB）磷酸化增加细胞周期蛋白D1（CCND1）的表达。此外，HNRNP A1与VRK 1 mRNA 3 'UTR顺式作用区的结合有助于增加肺癌细胞增殖。因此，我们的研究揭示了HNRNP A1通过转录后调节VRK 1表达在肺癌发生中的新作用，并表明其作为肺癌患者治疗靶点的潜力。
THeterogeneous nuclear ribonucleoprotein (HNRNP) A1 is the most abundant and ubiquitously expressed member of the HNRNP protein family. In recent years, it has become more evident that HNRNP A1 contributes to the development of neurodegenerative diseases. However, little is known about the underlying role of HNRNP A1 in cancer development. Here, we report that HNRNP A1 expression is significantly increased in lung cancer tissues and is negatively correlated with the overall survival of patients with lung cancer. Additionally, HNRNP A1 positively regulates vaccinia-related kinase 1 (VRK1) translation via binding directly to the 3′ untranslated region (UTR) of VRK1 mRNA, thus increasing cyclin D1 (CCND1) expression by VRK1-mediated phosphorylation of the cAMP response element–binding protein (CREB). Furthermore, HNRNP A1 binding to the cis-acting region of the 3′UTR of VRK1 mRNA contributes to increased lung cancer cell proliferation. Thus, our study unveils a novel role of HNRNP A1 in lung carcinogenesis via post-transcriptional regulation of VRK1 expression and suggests its potential as a therapeutic target for patients with lung cancer.
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影响因子：
11
作者：
Donev, R.;Newall, A.;Thome, J.;Sheer, D.
通讯作者：
Sheer, D.
DOI：
10.1155/2020/5632342
发表时间：
2020
期刊：
Analytical cellular pathology (Amsterdam)
影响因子：
--
作者：
Han X;Xiang X;Yang H;Zhang H;Liang S;Wei J;Yu J
通讯作者：
Yu J
影响因子：
--
作者：
Lee N;Kwon JH;Kim YB;Kim SH;Park SJ;Xu W;Jung HY;Kim KT;Wang HJ;Choi KY
通讯作者：
Choi KY
影响因子：
10.5
作者：
Kim, Tae-Don;Woo, Kyung-Chul;Kim, Kyong-Tai
通讯作者：
Kim, Kyong-Tai
影响因子：
5.3
作者：
Kang, Tae-Hong;Park, Do-Young;Kim, Kyong-Tai
通讯作者：
Kim, Kyong-Tai