Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: a systematic review and meta-analysis
Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: a systematic review and meta-analysis
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DOI：
10.1111/jcpe.12331
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发表时间：
2015-04-01
影响因子：
6.7
通讯作者：
Herrera, David
中科院分区：
文献类型：
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作者：
Serrano, Jorge;Escribano, Marta;Herrera, David
目的：在为期6个月的家庭随机临床试验(RCT)中，评价抗菌斑化学制剂治疗牙周炎的疗效。材料与方法设计了一套方案，包括纳入和排除标准，以确定评估牙龈和/或出血指数的RCT。电子搜索和手工搜索确定了相关论文，并对其进行了筛选和评估，以便纳入。检索全文并提取相关信息(也包括斑块指数)，包括质量和偏倚风险。结果通过筛选，共纳入87篇文献，133篇对照。被测试产品的附加效果在LOE&Silness牙龈指数(46个比较，wmd-0.217)、修改的牙龈指数(n=23，-0.415)、牙龈炎严重指数(n=26，-14.939%)或出血指数(n=23，-7.626%)方面有统计学意义，具有显著的异质性。对于菌斑，图雷斯基(66项研究，wmd-0.475)、Silness&Loe(n=26，-0.109)和菌斑严重程度(n=12，-23.4%)指数的其他影响被发现，具有显著的异质性。结论在本研究的局限性范围内，使用特定的化学试剂控制菌斑的配方在牙龈、出血和菌斑指数方面提供了统计上显著的改善。
AimThe aim of this systematic review was to evaluate the efficacy of anti-plaque chemical formulations for managing gingivitis, in 6-month, home-use, randomised clinical trials (RCTs).Material and MethodsA protocol was designed, including inclusion and exclusion criteria to identify RCTs assessing gingival and/or bleeding indices. Electronic and hand-searches identified relevant papers, which were screened and evaluated for inclusion. Full-papers were retrieved and relevant information was extracted (also plaque indices), including quality and risk of bias. Mean treatment effects were calculated to obtain weighted mean differences (WMD) and 95% confidence intervals.ResultsAfter the process of screening and selection, 87 articles with 133 comparisons, were included in the review. The additional effects of the tested products were statistically significant in terms of Loe & Silness gingival index (46 comparisons, WMD -0.217), modified gingival index (n=23, -0.415), gingivitis severity index (n=26, -14.939%) or bleeding index (n=23, -7.626%), with significant heterogeneity. For plaque, additional effects were found for Turesky (66 studies, WMD -0.475), Silness & Loe (n=26, -0.109), and plaque severity (n=12, -23.4%) indices, with significant heterogeneity.ConclusionWithin the limitations of the present study, formulations with specific agents for chemical plaque control provide statistically significant improvements in terms of gingival, bleeding and plaque indices.