A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double‐Blind, Placebo‐Controlled Study
A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double‐Blind, Placebo‐Controlled Study
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DOI：
10.1002/ptr.5680
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发表时间：
2016-11
影响因子：
7.2
通讯作者：
S. Begum;H. Jayalakshmi;H. G. Vidyavathi;G. Gopakumar;Issac Abin;Maliakel Balu;K. Geetha;S. Suresha;M. Vasundhara;Krishnakumar Im
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作者：
S. Begum;H. Jayalakshmi;H. G. Vidyavathi;G. Gopakumar;Issac Abin;Maliakel Balu;K. Geetha;S. Suresha;M. Vasundhara;Krishnakumar Im
尽管激素替代疗法的广泛使用，其副作用的各种报告产生了越来越多的兴趣，在开发安全的天然药物的管理绝经后不适。本随机、双盲、安慰剂对照研究调查了以1000 mg/天的剂量补充标准化胡芦巴提取物（胡芦巴）（FenuSMART™）90天对血浆雌激素和绝经后不适的影响。将88名患有中度至重度绝经后不适和生活质量差（根据格林更年期量表、简明SF-36®和结构化医学访谈的评分证明）的女性随机分配至浸提液治疗组（n = 44）或安慰剂组（n = 44）。与基线和安慰剂相比，提取物治疗组的血浆雌二醇（120%）显著增加（p < 0.01），各种绝经后不适和生活质量得到改善。虽然提取物组中有32%的受试者在补充后没有潮热，但其他受试者的潮热次数从基线阶段的每天3至5次减少到每天1至2次。血液学和生化参数的进一步分析揭示了提取物的安全性及其在绝经期妇女血脂管理中的合理作用。版权所有© 2016约翰威利父子有限公司.
Despite the widespread use of hormone replacement therapy, various reports on its side effects have generated an increasing interest in the development of safe natural agents for the management of postmenopausal discomforts. The present randomized, double‐blinded, placebo‐controlled study investigated the effect of 90‐day supplementation of a standardized extract of fenugreek (Trigonella foenum‐graecum) (FenuSMART™), at a dose of 1000 mg/day, on plasma estrogens and postmenopausal discomforts. Eighty‐eight women having moderate to severe postmenopausal discomforts and poor quality of life (as evidenced from the scores of Greene Climacteric Scale, short form SF‐36® and structured medical interview) were randomized either to extract‐treated (n = 44) or placebo (n = 44) groups. There was a significant (p < 0.01) increase in plasma estradiol (120%) and improvements on various postmenopausal discomforts and quality of life of the participants in the extract‐treated group, as compared with the baseline and placebo. While 32% of the subjects in the extract group reported no hot flashes after supplementation, the others had a reduction to one to two times per day from the baseline stages of three to five times a day. Further analysis of haematological and biochemical parameters revealed the safety of the extract and its plausible role in the management of lipid profile among menopausal women. Copyright © 2016 John Wiley & Sons, Ltd.