No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a Multicenter study
No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a Multicenter study
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DOI：
10.1016/j.biopsych.2004.06.017
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发表时间：
2004-09-01
影响因子：
10.6
通讯作者：
Yoshikawa, T
中科院分区：
文献类型：
--
作者：
Kunugi, H;Iijima, Y;Yoshikawa, T
背景：之前的两项研究报道了脑源性神经营养因子（BDNF）基因中的错义多态性（Val66Met）与躁郁症之间的显着关联；方法：我们组织了一项相对较大样本的多中心研究，其中包括 519 名双相情感障碍患者（根据 DSM-IV 标准）和 588 名性别、年龄和种族相匹配的对照受试者（日本人）。通过基于聚合酶链反应的限制性片段长度多态性或直接测序进行基因分型。结果：患者和对照受试者的基因型分布和等位基因频率相似。即使检查了多态性与多个临床变量（即双相情感障碍 I 或 II、是否存在精神病特征、家族史和发病年龄）的可能关系，也没有变量与多态性相关。结论：BDNF 基因的 Val66Met 多态性与双相情感障碍的发展或临床特征无关，至少在日本人群中是如此。
Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported necessitating further investigation.Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorders (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing.Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism.Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.