Transforming growth factor-beta: A target for cancer therapy
Transforming growth factor-beta: A target for cancer therapy
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DOI：
10.3109/15476910903389920
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发表时间：
2010-01-01
影响因子：
3.3
通讯作者：
Morris, John C.
中科院分区：
文献类型：
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作者：
Kelly, Ronan J.;Morris, John C.
转化生长因子-β（TGF-β）是调节细胞生长和分化、凋亡、细胞运动性、细胞外基质产生、血管生成和细胞免疫应答的多效性生长因子。TGF-β表现出自相矛盾的作用，从而它可以起到抑制早期肿瘤发生的作用;然而，它也可以通过操纵更适合肿瘤侵袭和转移发展的环境来促进恶性转化和刺激肿瘤生长。鉴于TGF-β在转化和癌症进展中的不可或缺的作用，TGF-β信号传导途径的各种组分为癌症治疗提供了潜在的有吸引力的治疗靶点。本文综述了TGF-β在癌症中的作用，并讨论了目前正在开发的靶向TGF-β、其受体及其信号通路沿着重要下游步骤的小分子和大分子药物。
Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor that regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immune responses. TGF-beta demonstrates paradoxical action whereby it can function to suppress early tumorigenesis; however, it can also facilitate malignant transformation and stimulate tumor growth by manipulating a more hospitable environment for tumor invasion and the development of metastases. Given the integral role of TGF-beta in transformation and cancer progression, various components of the TGF-beta signaling pathway offer potentially attractive therapeutic targets for cancer treatment. This review focuses on the role of TGF-beta in cancer and discusses both small and large molecule drugs currently in development that target TGF-beta, its receptor and important down stream steps along its signaling pathway.