Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer
Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer
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DOI：
10.1093/oxfordjournals.aje.a010052
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发表时间：
1999-09-15
影响因子：
5
通讯作者：
Craun, G
中科院分区：
文献类型：
--
作者：
Cantor, KP;Lynch, CF;Craun, G
作者在爱荷华州进行了一项基于人群的病例对照研究，研究对象为375名脑癌患者和2434名对照。邮寄问卷被用来收集关于终生居住史、饮用水来源、饮料摄入量和其他潜在风险因素的信息。通过将问卷数据与自来水公司的历史信息和最近样本中的三卤甲烷水平相结合，估计了饮用水中氯化副产品的暴露量。分析包括291例(77.6%)和1,983名对照(81.5%)，他们的一生中至少有70%的时间可以获得水质信息。代理人占案件总数的74.4%。直接受访者和代理受访者的平均居住地数量和平均居住时间相当，这表明对偏见的贡献很小。经多因素调整后，接触含氯地表水0、1-19年、20-39年和大于或等于40年的人群患脑癌的优势比分别为1.0、1.1、1.6和1.3(p趋势=0.1)，男性的优势比分别为1.0、1.3、1.7和2.5(p趋势=0.04)，女性分别为1.0、1.0、1.6和0.7(p趋势=0.7)。对三卤代甲烷平均寿命水平的估计也发现了类似的发现。在自来水消费量高于中位数的男性中，这种相关性更强。这些观察结果值得进一步关注，特别是考虑到胶质瘤发病率的上升。
The authors conducted a population-based case-control study in lowa of 375 brain cancer patients and 2,434 controls. A postal questionnaire was used to gather information on lifetime residential history, sources of drinking water, beverage intake, and other potential risk factors. Exposure to chlorination byproducts in drinking water was estimated by combining questionnaire data with historical information from water utilities and trihalomethane levels in recent samples. The analysis included 291 cases (77.6%) and 1,983 controls (81.5%), for whom water quality information was available for at least 70% of lifetime years. Proxies represented 74.4% of cases. The mean number and mean duration of places of residence were comparable between direct and proxy respondents, suggesting little contribution to bias. After multivariate adjustment, odds ratios for brain cancer were 1.0, 1.1, 1.6, and 1.3 for exposure to chlorinated surface water of 0, 1-19, 20-39, and greater than or equal to 40 years (p trend = 0.1), Among men, odds ratios were 1.0, 1.3, 1.7, and 2.5 (p trend = 0.04), and among women, 1.0, 1.0, 1.6, and 0.7 (p trend = 0.7)). Similar findings were found with estimates of average lifetime level of trihalomethanes. The association was stronger among men with above-median tap water consumption. These observations deserve further attention, especially in view of increasing glioma rates.