Depression and heart rate variability in patients with coronary heart disease.
Depression and heart rate variability in patients with coronary heart disease.
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DOI：
10.3949/ccjm.76.s2.03
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发表时间：
2009-04
影响因子：
6.1
通讯作者：
Freedland KE
中科院分区：
文献类型：
--
作者：
Carney RM;Freedland KE
抑郁在冠心病(CHD)患者中很常见，是这些患者心脏发病率和死亡率的危险因素。抑郁症与自主神经系统功能障碍有关，这至少可以部分解释这种风险的增加。低心率变异性(HRV)反映了交感神经和/或副交感神经对心率的过度调节和/或副交感神经调节不足，是冠心病患者死亡率的有力预测因子。大多数研究--包括稳定性冠心病患者和最近发生急性冠状动脉事件的患者--都发现抑郁症患者的HRV低于非抑郁症患者。这篇手稿提供了这篇文献的概述，并得出结论，HRV可能是CHD中与抑郁相关的风险的重要部分。
Depression is common in patients with coronary heart disease (CHD) and is a risk factor for cardiac morbidity and mortality in these patients. Depression is associated with autonomic nervous system dysfunction, which may at least partially explain this increased risk. Low heart rate variability (HRV), which reflects excessive sympathetic and/or inadequate parasympathetic modulation of heart rate, is a strong predictor of mortality in patients with CHD. Most studies—both in patients with stable CHD and in patients with a recent acute coronary event—have found HRV to be lower in depressed patients than in their nondepressed counterparts. This manuscript provides an overview of this literature and concludes that HRV may account for a substantial part of the risk associated with depression in CHD.