Scleroderma: the role of serum autoantibodies in defining specific clinical phenotypes and organ system involvement.
Scleroderma: the role of serum autoantibodies in defining specific clinical phenotypes and organ system involvement.
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DOI：
10.1097/bor.0000000000000113
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发表时间：
2014-11
影响因子：
5.1
通讯作者：
Domsic RT
中科院分区：
文献类型：
--
作者：
Domsic RT
探讨SSc相关抗体的血清学检测在该病诊断和预后方面的最新进展。2013年ACR/EULAR对SSC的临床分类标准纳入了SSC的临床分类标准，证明了SSC抗体对诊断的重要性。已经描述了两种新的SSc相关抗体及其临床相关性。多个队列研究报告了基于地理位置的不同抗体频率分布，但临床相关性基本相同。新的关联包括抗RNA聚合酶III抗体与胃窦血管扩张，以及SSC发病和RNA聚合酶III抗体之间的暂时关联。SSc相关抗体在诊断和内脏器官受累方面的作用和相关性越来越为人们所接受。
To discuss recent advances in serologic testing for SSc-associated antibodies with respect to the diagnosis and prognosis of the disease. The importance of SSc antibodies for diagnosis has become increasingly recognized, as evidence by incorporation into the 2013 ACR/EULAR clinical classification criteria for SSc. Two new SSc-associated antibodies and their clinical associations have been described. Multiple cohort studies have reported variable antibody frequency distribution based on geography, but the clinical associations remain much the same. New associations include anti-RNA polymerase III antibodies with gastric antral vascular ectasia, and a temporal association between SSc onset and RNA polymerase III antibodies. The role and associations of SSc-associated antibodies for diagnosis and internal organ involvement is becoming increasingly accepted.