THERMAL DOSE DETERMINATION IN CANCER-THERAPY
THERMAL DOSE DETERMINATION IN CANCER-THERAPY
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DOI：
10.1016/0360-3016(84)90379-1
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发表时间：
1984-01-01
影响因子：
7
通讯作者：
DEWEY, WC
中科院分区：
文献类型：
--
作者：
SAPARETO, SA;DEWEY, WC
随着临床热疗单独或与其他方式联合治疗癌症的快速发展，需要一种与临床生物效应相关的热剂量测量方法。通过对已发表数据的比较，可以得出一种可用于计算热剂量的基本关系。根据处理过程中温度作为时间函数的知识，结合时间-温度关系的数学描述，可以确定在某个参考温度下计算的暴露时间对实际处理的估计。这对于提供实际患者治疗期间的实时累积剂量有很大的好处。本研究的参考温度为43度。任意选择C来将所有热暴露转换为该温度下的等效分钟。该剂量计算可与度分钟的综合计算相比较，以确定其预后能力。这种等效剂量计算所依据的时间-温度关系既没有预测，也没有要求不同的组织对热具有相同的敏感性。包括一个用FORTRAN编写的计算机程序，用于计算等效分钟（t43）和度分钟（tdm43）。提供了改变参考温度、阿伦尼乌斯断裂温度以及断裂温度上下的时间-温度关系的方法。讨论了降温加热、热耐受性和生理条件等因素对热剂量计算的影响。所描述的方程和方法并非代表热剂量估计的唯一方法：相反，它们旨在为临床使用的这种计算提供一种简单但有效的方法，并促进以治疗上有用的热单位来评估数据的努力。
With the rapid development of clinical hyperthermia for the treatment of cancer alone or in conjunction with other modalities, a means of measuring a thermal dose in terms which are clinically relevant to the biological effect is needed. A comparison of published data empirically suggests a basic relationship that may be used to calculate a thermal dose. From a knowledge of the temperature during treatment as a function of time combined with a mathematical description of the time-temperature relationship, an estimate of the actual treatment calculated as an exposure time at some reference temperature can be determined. This could be of great benefit in providing a real-time accumulated dose during actual patient treatment. For the purpose of this study, a reference temperature of 43.degree. C was arbitrarily chosen to convert all thermal exposures to equivalent-minutes at this temperature. This dose calculation can be compared to an integrated calculation of the degree-minutes to determine its prognostic ability. The time-temperature relationship upon which this equivalent dose calculation is based does not predict, nor does it require, that different tissues have the same sensitivity to heat. A computer program written in FORTRAN is included for performing calculations of equivalent-minutes (t43) and degree-minutes (tdm43). Means are provided to alter the reference temperature, the Arrhenius break temperature and the time-temperature relationship above and below the break temperature. The effect of factors such as step-down heating, thermotolerance and physiological conditions on thermal dose calculations are discussed. The equations and methods described are not intended to represent the only approach for thermal dose estimation: instead, they are intended to provide a simple but effective means for such calculations for clinical use and to stimulate efforts to evaluate data in terms of therapeutically useful thermal units.