The anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands
The anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands
复制标题
DOI：
10.1016/j.ccr.2009.02.017
复制
发表时间：
2009-06
影响因子：
20.6
通讯作者：
R. W. Sun;C. Che
中科院分区：
文献类型：
--
作者：
R. W. Sun;C. Che
金（III）化合物长期以来一直被研究用于抗癌治疗。然而，其在溶液中的稳定性差往往阻碍了临床使用。大多数细胞毒性金 (III) 化合物通常都会将金 (III) 还原为金 (I)。此前，我们利用平面四齿双阴离子配体，包括卟啉、希夫碱和双(吡啶基)甲酰胺配体，制备了一系列单阳离子金(III)化合物。这些金(III)化合物表现为具有平面结构的有机亲脂阳离子，在生理条件下稳定，并具有一定的有前途的抗癌活性。在这篇综述中，介绍了这些金 (III) 化合物的合成、稳定性和抗癌特性。我们将详细介绍最有效的金(III)卟啉化合物[AuIII(TPP)]Cl (1a) 的体外和体内抗癌功效以及抗癌机制。
Gold(III) compounds have long been investigated for anti-cancer treatment. However, clinical use has often been hampered by their poor stability in solution. A reduction of gold(III) to gold(I) is usually the case for most cytotoxic gold(III) compounds. Previously, we made use of planar tetradentate dianionic ligands, including porphyrin, Schiff base and bis(pyridyl)carboxamide ligands, to prepare a series of monocationic gold(III) compounds. These gold(III) compounds behave as organic lipophilic cations with a planar structure, are stable under physiological conditions, and possess certain promising anti-cancer activities. In this review, the synthesis, stability, and anti-cancer properties of these gold(III) compounds are presented. We shall detail the in vitro and in vivo anti-cancer efficacy, as well as the anti-cancer mechanisms of the most potent gold(III) porphyrin compound [AuIII(TPP)]Cl (1a).