The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking.
The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking.
复制标题
神经激肽-1 受体在压力诱导的酒精和可卡因恢复中的作用。
DOI：
10.1038/npp.2013.309
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Schroeder,JasonP
中科院分区：
文献类型：
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作者：
Schank,JesseR;King,CourtneyE;Sun,Hui;Cheng,Kejun;Rice,KennerC;Heilig,Markus;Weinshenker,David;Schroeder,JasonP
神经激肽-1受体（NK 1 R）已被证明介导酒精和阿片类药物，但不介导啮齿动物对可卡因的奖赏。我们最近报道，NK 1 R拮抗作用也阻断了大鼠应激诱导的酒精寻求恢复，但目前尚不清楚这些抗复发特性是否延伸到其他药物类别。虽然一些研究表明，颅内P物质（SP）输注恢复可卡因寻求消失后，没有研究表明，在恢复可卡因寻求的NK 1 R的直接作用。在这里，我们探讨了NK 1 R拮抗剂L 822429对育亨宾诱导的Long-Evans大鼠酒精或可卡因寻求恢复的影响。与我们先前在Wistar大鼠中发现的足震诱导的酒精寻求恢复一致，我们发现L 822429减弱育亨宾诱导的酒精寻求恢复，但不影响基线酒精自我给药。我们观察到类似的抑制育亨宾诱导的可卡因寻求恢复L 822429，并发现Long-Evans大鼠表现出更大的敏感性NK 1 R拮抗比Wistar大鼠。因此，Long-Evans大鼠在某些皮层下脑区表现出NK 1 Rs表达的差异。结合，我们的研究结果表明，虽然NK 1 R拮抗作用对酒精和可卡因相关行为的影响不同，但该受体介导了两种药物的应激诱导寻求。
Neurokinin-1 receptors (NK1Rs) have been shown to mediate alcohol and opiate, but not cocaine reward in rodents. We recently reported that NK1R antagonism also blocks stress-induced reinstatement of alcohol seeking in rats, but it is presently unknown whether these antirelapse properties extend to other drug classes. Although some work has suggested that intracranial substance P (SP) infusion reinstates cocaine seeking following extinction, no studies have indicated a direct role for the NK1R in reinstatement of cocaine seeking. Here, we explored the effect of the NK1R antagonist L822429 on yohimbine-induced reinstatement of alcohol or cocaine seeking in Long–Evans rats. Consistent with our previous findings with footshock-induced reinstatement of alcohol seeking in Wistar rats, we found that L822429 attenuates yohimbine-induced reinstatement of alcohol seeking, but does not affect baseline alcohol self-administration. We observed a similar suppression of yohimbine-induced reinstatement of cocaine seeking by L822429, and found that Long–Evans rats exhibit greater sensitivity to NK1R antagonism than Wistar rats. Accordingly, Long–Evans rats exhibit differences in the expression of NK1Rs in some subcortical brain regions. Combined, our findings suggest that while NK1R antagonism differentially influences alcohol-and cocaine-related behavior, this receptor mediates stress-induced seeking of both drugs.