Cerium Oxide Nanoparticles Improve Outcome after In Vitro and In Vivo Mild Traumatic Brain Injury.
Cerium Oxide Nanoparticles Improve Outcome after In Vitro and In Vivo Mild Traumatic Brain Injury.
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体外和体内轻度创伤性脑损伤后，氧化葡萄纳米颗粒改善了预后。
DOI：
10.1089/neu.2016.4644
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发表时间：
2020-06-15
影响因子：
4.2
通讯作者：
Rzigalinski BA
中科院分区：
文献类型：
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作者：
Bailey ZS;Nilson E;Bates JA;Oyalowo A;Hockey KS;Sajja VSSS;Thorpe C;Rogers H;Dunn B;Frey AS;Billings MJ;Sholar CA;Hermundstad A;Kumar C;VandeVord PJ;Rzigalinski BA
轻度创伤性脑损伤导致异常自由基产生，这与氧化应激、继发性损伤信号级联、线粒体功能障碍和不良功能结局相关。抗氧化剂对自由基的药理靶向作用已被视为一种治疗方法，但在临床试验中取得的成功有限。目前可用的常规抗氧化剂在过程中被破坏之前会破坏单个自由基。在这里，我们首次报道了一种新的再生氧化铈纳米颗粒抗氧化剂在体外创伤后减少神经元死亡和钙失调。此外，使用在大鼠中的轻度侧向液压冲击脑损伤的体内模型，我们报告说，氧化铈纳米颗粒还保存内源性抗氧化系统，减少大分子自由基损伤，并改善认知功能。总之，我们的研究结果表明，氧化铈纳米颗粒是一种新型的纳米药物，有可能减轻轻度创伤性脑损伤的神经病理学影响，并修改恢复过程。
Mild traumatic brain injury results in aberrant free radical generation, which is associated with oxidative stress, secondary injury signaling cascades, mitochondrial dysfunction, and poor functional outcome. Pharmacological targeting of free radicals with antioxidants has been examined as an approach to treatment, but has met with limited success in clinical trials. Conventional antioxidants that are currently available scavenge a single free radical before they are destroyed in the process. Here, we report for the first time that a novel regenerative cerium oxide nanoparticle antioxidant reduces neuronal death and calcium dysregulation after in vitro trauma. Further, using an in vivo model of mild lateral fluid percussion brain injury in the rat, we report that cerium oxide nanoparticles also preserve endogenous antioxidant systems, decrease macromolecular free radical damage, and improve cognitive function. Taken together, our results demonstrate that cerium oxide nanoparticles are a novel nanopharmaceutical with potential for mitigating neuropathological effects of mild traumatic brain injury and modifying the course of recovery.
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影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
4.2
作者：
Hylin, Michael J.;Orsi, Sara A.;Dash, Pramod K.
通讯作者：
Dash, Pramod K.
影响因子：
4.7
作者：
Ahmed, SM;Rzigalinski, BA;Ellis, EF
通讯作者：
Ellis, EF
影响因子：
4.1
作者：
KONTOS, HA;WEI, EP
通讯作者：
WEI, EP
影响因子：
6.2
作者：
Aneggi, E;Boaro, M;Trovarelli, A
通讯作者：
Trovarelli, A