Performance evaluation of an automatic controlled sonoporation therapy device
Performance evaluation of an automatic controlled sonoporation therapy device
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自动控制声孔治疗装置的性能评价
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Georg Schmitz
中科院分区：
文献类型：
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作者：
K. Hensel;Georg Schmitz
声孔效应是超声作用下细胞膜的瞬时非特异性渗透性，微泡的存在会增加这种渗透性。治疗成功在很大程度上取决于声激励的参数。高声压导致大量的死细胞，而低压力导致低的声穿孔速率。然而，反射界面处的组织衰减和相长波干涉抑制了治疗部位处的压力的可靠预测。因此，我们开发了一种声致穿孔装置，通过声学观察微泡破坏和组织衰减估计来自动控制治疗部位的压力。声孔装置由定制设计的1 MHz治疗换能器组成，该换能器具有用于可编程医用超声机的成像阵列的中心开口。成像阵列允许在治疗之前和治疗期间对治疗焦点进行图像引导定位，并监测MB行为。通过结合微泡破坏检测和衰减估计的算法来估计所得到的组织传递函数，以控制治疗部位处的压力。对于性能评价，使用了在具有不同衰减的组织模拟体模中具有SonoVue微泡溶液流的流动体模。一个评估控制序列与PI控制器显示了一个改进的RMSE为5.5%相比，7.7%，没有调节到700 kPa的设定点。本研究显示所提出的声穿孔装置通过微泡破坏检测和衰减估计来控制治疗压力的可行性。
Sonoporation is the transient unspecific permeability of the cell membrane by ultrasound, which is increased by the presence of microbubbles. Therapy success strongly depends on the parameters of the acoustic excitation. High sound pressures cause high numbers of dead cells, whereas low pressures result in low sonoporation rates. However, tissue attenuation and constructive wave interference at reflecting interfaces inhibit reliable prediction of pressure at the therapy site. Consequently, we developed a sonoporation device allowing automatic control of the pressure at the therapy site by acoustic observation of microbubble destruction and tissue attenuation estimation. The sonoporation device consists of a custom designed 1 MHz therapy transducer with a central opening for an imaging array of a programmable medical ultrasound machine. The imaging array allows image guided positioning of the therapy focus before and during therapy and the monitoring of MB behavior. The resulting tissue transfer function is estimated by an algorithm combining microbubble destruction detection and attenuation estimation to control the pressure at the therapy site. For performance evaluation, a flow phantom with a flow of SonoVue microbubble solution in a tissue mimicking phantom with varying attenuation was used. An evaluation control sequence with a PI controller revealed an improved RMSE of 5.5% compared to 7.7% without the regulation to a set point of 700 kPa. This study shows the feasibility of the presented sonoporation device to control therapy pressure by microbubble destruction detection and attenuation estimation.
影响因子：
2.9
作者：
Azencott, Harold R.;Peter, Gary F.;Prausnitz, Mark R.
通讯作者：
Prausnitz, Mark R.