A Cellulose/Chitosan Dual Cross-Linked Multifunctional and Resilient Hydrogel for Emergent Open Wound Management.
A Cellulose/Chitosan Dual Cross-Linked Multifunctional and Resilient Hydrogel for Emergent Open Wound Management.
复制标题
用于紧急开放性伤口处理的纤维素/壳聚糖双交联多功能弹性水凝胶。
DOI：
10.1002/adhm.202304676
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发表时间：
2024
影响因子：
10
通讯作者：
Lu S
中科院分区：
文献类型：
--
作者：
Lu S
粘性水凝胶在生物医学应用中具有巨大的潜力，例如在门诊治疗或手术期间的止血和紧急伤口管理。然而，大多数粘性水凝胶在湿组织上提供牢固的粘附方面表现不佳，增加了出血的风险并降低了手术的容错性。为了解决这个问题，这项工作开发了一种基于多糖的生物粘附性水凝胶胶带（ACAN），由烯丙基纤维素（AC）和羧甲基壳聚糖（CMCS）的双重交联组成。AC和CMCS网络的吸湿性使ACAN能够从组织表面去除界面水并立即消除物理交联。随后，与胺部分形成共价交联，以维持长期和稳健的粘合。双交联ACAN还具有良好的细胞相容性，具有与组织相匹配的可控机械性能，其中添加的CMCS提供了显着的抗菌性能和止血能力。与市售的3M膜相比，ACAN膜具有超快的伤口愈合速度. ACAN混合水凝胶具有生物相容性和抗菌、止血和伤口愈合特性等优点，为急救胶带设计提供了新的思路，并推动了纤维素基材料技术在高性能生物医学应用中的发展。
Adhesive hydrogel holds huge potential in biomedical applications, such as hemostasis and emergent wound management during outpatient treatment or surgery. However, most adhesive hydrogels underperform to offer robust adhesions on the wet tissue, increasing the risk of hemorrhage and reducing the fault tolerance of surgery. To address this issue, this work develops a polysaccharide‐based bioadhesive hydrogel tape (ACAN) consisting of dual cross‐linking of allyl cellulose (AC) and carboxymethyl chitosan (CMCS). The hygroscopicity of AC and CMCS networks enables ACAN to remove interfacial water from the tissue surface and initializes a physical cross‐link instantly. Subsequently, covalent cross‐links are developed with amine moieties to sustain long‐term and robust adhesion. The dual cross‐linked ACAN also has good cytocompatibility with controllable mechanical properties matching to the tissue, where the addition of CMCS provides remarkable antibacterial properties and hemostatic capability. Moreover, compared with commercially available 3 M film, ACAN provides an ultrafast wound healing on tissue. The ACAN hybrid hydrogels have advantages such as biocompatibility and antibacterial, hemostatic, and wound healing properties, shedding new light on first‐aid tape design and advancing the cellulose‐based materials technology for high‐performance biomedical applications.