Pulse-driven magnetoimpedance sensor detection of biomagnetic fields in musculatures with spontaneous electric activity
Pulse-driven magnetoimpedance sensor detection of biomagnetic fields in musculatures with spontaneous electric activity
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DOI：
10.1016/j.bios.2011.05.041
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发表时间：
2011-09-15
影响因子：
12.6
通讯作者：
Uchiyama, Tsuyoshi
中科院分区：
文献类型：
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作者：
Nakayama, Shinsuke;Atsuta, Satoshi;Uchiyama, Tsuyoshi
我们测量生物磁场的肌肉组织与自发电活动，使用脉冲驱动的磁阻抗（PMI）传感器的灵敏度提高到一个皮特斯拉（pT）的水平。由于1 μ s的足够短的操作间隔，该磁传感器能够准实时记录生物电活动的磁场。将来自豚鼠胃、盲肠带、门静脉和膀胱的分离小肌肉组织在体温下的器官浴中孵育。安装在制剂下方约1 mm处的改进的PMI传感器检测反映肌肉组织制剂的自发电活动的振荡磁场。在带绦虫盲肠，应用四乙基铵（TEA），一种K+通道阻断剂，显着增强的磁活动估计直方图分析。此外，在一些肌肉组织的准备，同时测量与电活动显示，所观察到的磁活动归因于生物电活动。PMI技术在生物学和医学领域的应用前景广阔。(C)2011 Elsevier B.V.保留所有权利。
We measured biomagnetic fields in musculatures with spontaneous electric activity using a pulse-driven magnetoimpedance (PMI) sensor with the sensitivity improved toward a pico-Tesla (pT) level. Due to the sufficiently short operation interval of 1 mu s, this magnetic sensor enabled quasi-real time recordings of the magnetic field for biological electric activity. Isolated small musculatures from the guinea-pig stomach, taenia caeci, portal vein and urinary bladder were incubated in an organ bath at a body temperature. The improved PMI sensor mounted approximately 1 mm below the preparations detected oscillatory magnetic fields reflecting spontaneous electric activities of musculature preparations. In the taenia caeci, application of tetraethyl ammonium (TEA), a K+ channel blocker, significantly enhanced the magnetic activity estimated by histogram analysis. Also, in some musculature preparations, simultaneous measurements with electric activity revealed that the observed magnetic activities were attributed to biological electric activity. PMI technology is promising for applications in biology and medicine. (C) 2011 Elsevier B.V. All rights reserved.