Trends in the clinical stage distribution of breast cancer in Osaka, Japan

Trends in the clinical stage distribution of breast cancer in Osaka, Japan
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DOI：
10.1007/s12282-017-0807-7
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发表时间：
2018-03-01
期刊：
BREAST CANCER
影响因子：
4
通讯作者：
Maeura, Yoshiichi
Maeura, Yoshiichi
中科院分区：
医学3区
文献类型：
--
作者：
Toyoda, Yasuhiro;Tabuchi, Takahiro;Maeura, Yoshiichi

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我们使用1980年至2012年期间基于人群的癌症登记研究，检查了日本大坂女性乳腺癌病例中筛查发现的乳腺癌病例比例和年龄组的临床分期分布。在研究期间，本地病例的比例逐渐增加，区域病例的比例逐渐减少。远距离病例的比例趋于稳定。2003年后，原地病例的比例迅速增加。在30-39岁、40-49岁、50-59岁和60-69岁的妇女中，这一增长是明显的。2010-2012年，40-49岁、50-59岁和60-69岁妇女的原位病例比例分别达到15.4%、11.3%和9.9%。关于筛查状况，1988年之前筛查发现的病例比例低于3%。在1989年至2003年期间，它稳定在5%左右。2003年以后，这一比例明显上升，达到25.4%：40-49岁为34.0%，50-59岁为32.8%，60-69岁为26.7%。当地病例增加和区域病例减少的原因可能是人们对乳腺癌的认识，这可能是医疗诊断技术发展的结果。另一方面，原地病例的急剧增加可能是由于筛查。我们需要仔细监测临床阶段乳腺癌发病率的趋势。
We examined the proportion of screen-detected breast cancer cases and clinical stage distribution by age group among female breast cancer cases in Osaka, Japan using population-based cancer registry from the period 1980 to 2012. The proportion of local cases increased and that of regional cases decreased gradually during the study period. The proportion of distant cases leveled off. The proportion of in situ cases increased rapidly after 2003. This increase was noticeable for women aged 30-39, 40-49, 50-59, and 60-69 years. The proportion of in situ cases for women aged 40-49, 50-59, and 60-69 years reached 15.4, 11.3, and 9.9% in 2010-2012, respectively. Regarding screening status, the proportion of screen-detected cases before 1988 was under 3%. Between 1989 and 2003, it leveled off at around 5%. After 2003, the proportion increased noticeably, and reached 25.4%:34.0% in aged 40-49 years, 32.8% in aged 50-59 years, and 26.7% in aged 60-69 years. The increase in local cases and decrease in regional cases would be due to awareness of breast cancer, probably a result of developments in medical diagnostic technology. On the other hand, the steep increase of in situ cases might be due to screening. We need careful monitoring of the trends in breast cancer incidence by clinical stage.