Renin Substrates. Part 1. Liquid-Phase Synthesis of the Equine Sequence with Benzotriazolyloxytris(dimethylamino)phosphonium Hexafluorophosphate (BOP).
Renin Substrates. Part 1. Liquid-Phase Synthesis of the Equine Sequence with Benzotriazolyloxytris(dimethylamino)phosphonium Hexafluorophosphate (BOP).
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肾素底物。
DOI：
10.1002/chin.198537326
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
B. Castro
中科院分区：
文献类型：
--
作者：
D. L. Nguyen;R. Seyer;A. Heitz;B. Castro
通过三段偶联策略合成了四肽Ac-Asp1-Arg2-Val3-Tyr4-lle5-His6-Pro7-Phe8-His9-Leu10-Leu11-Val12-Tyr13-Ser14-OH。所有的偶联步骤都是用苯并三唑氧基二甲基氨基六氟磷酸磷（BOP试剂）进行的。用Boc（ni -Boc）组氨酸（DCHA）掺入组氨酸收率较高。
The tetradecapeptide Ac-Asp1-Arg2-Val3-Tyr4-lle5-His6-Pro7-Phe8-His9-Leu10-Leu11-Val12-Tyr13-Ser14-OH has been synthesized by a three-segment coupling strategy. All the coupling steps were carried out with benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP reagent). Histidine was incorporated in good yield by using Boc(Nim-Boc)histidine (DCHA).