Oxidation of gem-borylsilylalkylcoppers to acylsilanes with air
Oxidation of gem-borylsilylalkylcoppers to acylsilanes with air
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DOI：
10.1021/ol0600988
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发表时间：
2006-03-16
期刊：
影响因子：
5.2
通讯作者：
Oshima, K
中科院分区：
文献类型：
--
作者：
Kondo, J;Shinokubo, H;Oshima, K
1-硼基-1-硅烷基铜在吡啶存在下与分子氧反应，有效地得到酰基硅烷。该一锅法包括两个反应：在氰化铜（I）存在下用格氏试剂烷基化1-硼基-1-氯-甲硅烷基甲基锂和烷基铜物种的有氧氧化。这一过程使我们能够获得不同的合成酰基硅烷。
1-Boryl-1-silylalkylcoppers react with molecular oxygen in the presence of pyridine to afford acylsilanes efficiently. The one-pot process consists of two reactions: alkylation of 1-boryl-1-chloro-silylmethyllithium with Grignard reagents in the presence of copper(l) cyanide and aerobic oxidation of the alkylcopper species. This procedure enables us to access the divergent synthesis of acylsilanes.