Extracorporeal life support in cardiovascular patients with observed refractory in-hospital cardiac arrest is associated with favourable short and long-term outcomes: A propensity-matched analysis
Extracorporeal life support in cardiovascular patients with observed refractory in-hospital cardiac arrest is associated with favourable short and long-term outcomes: A propensity-matched analysis
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DOI：
10.1177/2048872615612454
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发表时间：
2016-11-01
影响因子：
4.1
通讯作者：
Moellmann, Helge
中科院分区：
文献类型：
--
作者：
Blumenstein, Johannes;Leick, Juergen;Moellmann, Helge
目的：体外生命支持（ECLS）在院内心脏骤停患者中显示出令人鼓舞的生存率;然而，其常规使用仍存在争议。我们比较了在医院心脏骤停接受常规心肺复苏（CCPR）的患者与ECLS作为辅助心肺复苏（ECPR）的患者的生存率（ECPR）。方法：共有353例在医院心脏骤停（272 CCPR和52 ECPR）的患者纳入本回顾性，倾向评分调整（1：1匹配），单中心研究。结果：在非匹配组中，接受ECPR的患者最初的APACHE II评分明显高于对照组（P=0.03），去甲肾上腺素剂量增加（P = 0.03），肌酸激酶水平升高（P= 0.001）。
Aims: Extracorporeal life support (ECLS) has shown encouraging survival rates in patients with in-hospital cardiac arrest; however, its routine use is still controversial. We compared the survival of patients with in-hospital cardiac arrest receiving conventional cardiopulmonary resuscitation (CCPR) to that of patients with ECLS as an adjunct to cardiopulmonary resuscitation (ECPR).Methods: A total of 353 patients with in-hospital cardiac arrest (272 CCPR and 52 ECPR) were included in this retrospective, propensity score-adjusted (1:1 matched), single-centre study. Primary endpoints were survival at 30 days, long-term survival and neurological outcome defined by the cerebral performance categories score.Results: In the unmatched groups patients undergoing ECPR initially had significantly higher APACHE II scores (P=0.03), increased norepinephrine dosages (P=0.03) and elevated levels of creatine kinase (P