Properties of the Cognitive Function Battery for the MIND Diet Intervention to Prevent Alzheimer's Disease.
Properties of the Cognitive Function Battery for the MIND Diet Intervention to Prevent Alzheimer's Disease.
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DOI：
10.1017/s1355617721001089
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发表时间：
2022-09
期刊：
影响因子：
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通讯作者：
Barnes LL
中科院分区：
文献类型：
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作者：
Krueger KR;Dhana K;Aggarwal NT;Arfanakis K;Carey VJ;Sacks FM;Barnes LL
评估MIND饮食干预预防阿尔茨海默病中使用的认知组合的特性。MIND饮食干预是一项随机对照试验，旨在确定MIND饮食在减缓认知能力下降和减少老年人脑萎缩方面的相对有效性。MIND认知功能电池在基线时对604名平均年龄为70岁的参与者进行管理，他们同意参加饮食干预研究，并旨在测量随时间的变化。该组合包括12项认知测试，测量执行功能、感知速度、情景记忆和语义记忆这四个认知领域。我们进行了主成分分析，以检查我们的理论领域和参与者在每个领域的统计表现之间的一致性。为了进一步确定每个领域的有效性，我们将领域分数与晚年认知活动分数进行回归，控制年龄，种族，性别和教育年限。在主成分分析中出现了四个与理论域相似的因子。在回归方程中，我们发现了年龄，教育和晚年认知活动与四个认知领域中的每一个的预期关联。这些结果表明，MIND认知组合是一个全面有效的组合，包含四个独立的认知功能领域，可用于老年人的饮食干预试验。
To evaluate the properties of the cognitive battery used in the MIND Diet Intervention to Prevent Alzheimer’s Disease. The MIND Diet Intervention is a randomized control trial to determine the relative effectiveness of the MIND diet in slowing cognitive decline and reducing brain atrophy in older adults at risk for Alzheimer’s dementia. The MIND cognitive function battery was administered at baseline to 604 participants of an average age of 70 years, who agreed to participate in the diet intervention study, and was designed to measure change over time. The battery included 12 cognitive tests, measuring the four cognitive domains of executive function, perceptual speed, episodic memory, and semantic memory. We conducted a principal component analysis to examine the consistency between our theoretical domains and the statistical performance of participants in each domain. To further establish the validity of each domain, we regressed the domain scores against a late life cognitive activity score, controlling for age, race, sex, and years of education. Four factors emerged in the principal component analyses that were similar to the theoretical domains. In regression equations, we found the expected associations with age, education, and late life cognitive activity with each of the four cognitive domains. These results indicate that the MIND cognitive battery is a comprehensive and valid battery of four separate domains of cognitive function that can be used in diet intervention trials for older adults.