Vanadium complexes with mixed O,S anionic ligands derived from maltol:: Synthesis, characterization, and biological studies
Vanadium complexes with mixed O,S anionic ligands derived from maltol:: Synthesis, characterization, and biological studies
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DOI：
10.1021/ic0486926
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发表时间：
2005-04-18
影响因子：
4.6
通讯作者：
Orvig, C
中科院分区：
文献类型：
--
作者：
Monga, V;Thompson, KH;Orvig, C
从麦芽酚（3-羟基-2-甲基-4-吡喃酮）衍生的四种混合O，S双齿配体前体与钒螯合，得到了新的双（配体）氧钒（IV）和三（配体）钒（III）配合物。四种配体前体包括两种吡喃硫酮，3-羟基-2-甲基-4-吡喃硫酮，通常称为硫代麦芽酚（Htma），和2-乙基-3-羟基-4-吡喃硫酮，通常称为乙基硫代麦芽酚（Hetma），以及两种吡啶硫酮，3-羟基-2-甲基-4（H）-吡啶硫酮（Hmppt）和3-羟基-1，2-二甲基-4-吡啶硫酮（Hdppt）。通过元素分析、质谱法和IR和EPR（在可能的情况下）光谱法确认钒络合物的形成。氧代双（硫代麦芽酚）钒（IV），VO（tma）（2）的X-射线结构也被确定;顺式和反式异构体被分离在同一个不对称单元。在这两种异构体中，两个硫代麦芽酚酸配体围绕着四棱锥的底部排列，V=O键垂直;钒原子稍微偏离底面[V（1）= 0.656（3）埃，V（2）= 0.664（2）埃]。所有的新的配合物进行了筛选，在链脲佐菌素诱导的糖尿病大鼠的胰岛素增强效果，VO（tma）2的代谢分析尿钒和配体清除GFAAS和ESIMS，分别。新的钒配合物没有降低血糖水平急性，可能是因为快速解离和排泄。
Four mixed O,S binding bidentate ligand precursors derived from maltol (3-hydroxy-2-methyl-4-pyrone) have been chelated to vanadium to yield new bis(ligand)oxovanadium(IV) and tris(ligand)vanadium(III) complexes. The four ligand precursors include two pyranthiones, 3-hydroxy-2- m ethyl-4-pyranthione, commonly known as thiomaltol (Htma), and 2-ethyl-3-hydroxy-4-pyranthione, commonly known as ethylthiomaltol (Hetma), as well as two pyridinethiones, 3-hydroxy-2-methyl-4(H)-pyridinethione (Hmppt) and 3-hydroxy-1,2-dimethyi-4-pyridinethione (Hdppt). Vanadium complex formation was confirmed by elemental analysis, mass spectrometry, and IR and EPR (where possible) spectroscopies. The X-ray structure of oxobis(thiomaltolato)vanadium(IV),VO(tma)(2), was also determined; both cis and trans isomers were isolated in the same asymmetric unit. In both isomers, the two thiomaltolato ligands are arranged around the base of the square pyramid with the V=O linkage perpendicular; the vanadium atom is slightly displaced from the basal plane [V(1) = 0.656(3) angstrom, V(2) = 0.664(2) angstrom]. All of the new complexes were screened for insulin-enhancing effectiveness in streptozotocin-induced diabetes in rats, and VO(tma)2 was profiled metabolically for urinary vanadium and ligand clearance by GFAAS and ESIMS, respectively. The new vanadium complexes did not lower blood glucose levels acutely, possibly because of rapid dissociation and excretion.