The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase
The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase
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DOI：
10.1016/s0040-4039(01)02137-2
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发表时间：
2002-01-07
影响因子：
1.8
通讯作者：
Nishiyama, S
中科院分区：
文献类型：
--
作者：
Iikubo, K;Ishikawa, Y;Nishiyama, S
已经实现了α -山竹苷1a的全合成。在PPh3-CCl4条件下进行了构建山酮骨架的关键环化反应。讨论了1a和二苯甲酮中间体16对酸性鞘脂酰化酶的抑制作用。(C) 2002 Elsevier Science Ltd.版权所有。
A total synthesis of alpha-mangostin 1a has been achieved. The key cyclization reaction to construct the xanthone framework was undertaken by employing the PPh3-CCl4 conditions. The inhibitory activities of 1a and the benzophenone intermediate 16 against the acidic sphingonlyelinase were discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.