Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data.
Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data.
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DOI：
10.3109/02656736.2010.487194
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Jones EL
中科院分区：
文献类型：
--
作者：
Zagar TM;Oleson JR;Vujaskovic Z;Dewhirst MW;Craciunescu OI;Blackwell KL;Prosnitz LR;Jones EL
长期以来，热疗一直与放射治疗相结合，用于治疗浅表恶性肿瘤，部分原因是它具有放射增敏能力。乳腺癌表面复发的患者，无论是乳房切除后的胸壁复发，还是乳房保乳后的乳房复发，临床结果通常都很差。他们经常患上远处转移性疾病，但我们不能忽视与失控的局部失败相关的问题。发病率很高，可能会严重影响生活质量。在治疗乳腺癌的表面复发方面，特别是在以前接受过放射治疗的患者中，没有公认的护理标准。有大量文献关于联合使用热疗和放射治疗来治疗这些浅表复发。其中大部分是回溯性的，但有几个更大的III期随机试验表明，同时接受这两种方法治疗的患者的临床完全应答率有所提高。在这篇综述文章中，我们将重点介绍已发表的有关热疗和辐射联合使用的重要前瞻性数据。
Hyperthermia has long been used in combination with radiation for the treatment of superficial malignancies, in part due to its radiosensitising capabilities. Patients who suffer superficial recurrences of breast cancer, be it in their chest wall following mastectomy, or in their breast after breast conservation, typically have poor clinical outcomes. They often develop distant metastatic disease, but one must not overlook the problems associated with an uncontrolled local failure. Morbidity is enormous, and can significantly impair quality of life. There is no accepted standard of care in treating superficial recurrences of breast cancer, particularly in patients that have previously been irradiated. There is a substantial literature regarding the combined use of hyperthermia and radiotherapy for these superficial recurrences. Most of it is retrospective in nature, but there are several larger phase III randomised trials that show an improved rate of clinical complete response in patients treated with both modalities. In this review article, we will highlight the important prospective data that has been published regarding the combined use of hyperthermia and radiation.
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DOI：
10.1016/s0360-3016(97)00740-2
发表时间：
1998-01-15
影响因子：
7
作者：
Lee, HK;Antell, AG;Lockett, MA
通讯作者：
Lockett, MA
影响因子：
45.3
作者：
BECK, TM;HART, NE;SMITH, CE
通讯作者：
SMITH, CE
影响因子：
3.5
作者：
Dewhirst, MW
通讯作者：
Dewhirst, MW
影响因子：
3.7
作者：
Chagpar, A;Meric-Bernstam, F;Kuerer, HM
通讯作者：
Kuerer, HM
DOI：
10.1016/0360-3016(92)90743-2
发表时间：
1992-01-01
影响因子：
7
作者：
HALVERSON, KJ;PEREZ, CA;FINEBERG, B
通讯作者：
FINEBERG, B