Radiofrequency Encoded Combinatorial Chemistry
Radiofrequency Encoded Combinatorial Chemistry
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DOI：
10.1002/anie.199522891
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发表时间：
1995-11
影响因子：
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通讯作者：
K. Nicolaou;Xiao-yi Xiao-Xiao-yi-Xiao-144962926;Z. Parandoosh;A. Senyei;M. Nova
中科院分区：
文献类型：
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作者：
K. Nicolaou;Xiao-yi Xiao-Xiao-yi-Xiao-144962926;Z. Parandoosh;A. Senyei;M. Nova
组合化学“最近被认为是药物发现和材料科学的有力工具”。[31虽然这种方法在这些领域的潜力是巨大的，但其目前的范围受到几个因素的限制。特别令人不快的是缺乏一种通用的编码系统，用于遵循导致化学构建体的合成序列，从而可以促进结构表征。尽管引入了几种编码。[41物理和去卷积技术用于鉴定化学文库中的成员，仍然存在严重的实际问题，并且需要对该问题的更普遍和实际的解决方案。我们在这里介绍了一个新的概念，编码组合化学库的基础上，射频信号和半导体存储设备，使用多功能微反应器。辐射编码组合化学（RECTM）这种新方法结合了微电子学、传感器和化学的最新进展，并使用单或多可寻址辐射标记（SMARTTM）半导体单元来记录编码和沿合成途径的其他相关信息沿着。这允许通过检索记录的历史和其他特定信息来识别库成员，
Combinatorial chemistry"'has recently been recognized as a powerful tool in drug discovery"] and materials science.[31 Although the potential of this method in these areas is enormous, its current scope is limited by several factors."'Particularly prohibitive is the lack of a general encoding system for following the synthetic sequence leading to the chemical constructs so that structural characterization can be facilitated. Despite the introduction of several encoding.[41 physicaL1'] and deconvolution 161 techniques for identification of members in a chemical library, serious practical issues still remain and a more general and practical solution to this problem is needed. We introduce here a new concept for encoding combinatorial chemical libraries based on radiofrequency signals and semiconductor memory devices using a multifunctional Microreactor. Radiofrequency Encoded Combinatorial (RECTM) chemistry. as this new method is termed, combines recent advances in microelectronics, sensors, and chemistry and uses a Single or Multiple Addressable Radiofrequency Tag (SMARTTM) semiconductor unit ['] to record encoding and other relevant information along the synthetic pathway. This allows identification of library members by retrieval of the recorded history and other specific information re-