Characterizing longitudinal white matter development during early childhood.
Characterizing longitudinal white matter development during early childhood.
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在童年时期表征纵向白质的发展。
DOI：
10.1007/s00429-014-0763-3
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发表时间：
2015-07
影响因子：
3.1
通讯作者：
Deoni SC
中科院分区：
文献类型：
--
作者：
Dean DC 3rd;O'Muircheartaigh J;Dirks H;Waskiewicz N;Walker L;Doernberg E;Piryatinsky I;Deoni SC
尸检研究表明，大脑有髓鞘的白色物质的成熟，对有效和协调的大脑交流至关重要，遵循一种非线性的时空模式，与认知功能和行为的开始和完善相对应。不幸的是，在体内髓鞘形成的调查是具有挑战性的，因此，鲜为人知的是髓鞘形成的规范模式，或其与功能发育的关联。我们使用一种对髓鞘敏感的新型定量磁共振成像技术，检查了108名年龄从2.5个月到5.5岁不等的典型发育儿童的纵向白色物质发育。使用非线性混合效应模型，我们提供了第一个在体内纵向描述髓鞘水分数的发展。此外，我们表现出不同的男性和女性的发展模式，并证明髓鞘含量和认知功能的措施之间的显着关系。这些发现推进了对健康大脑发育的新理解，并为评估非典型发育提供了基础。本文的在线版本（doi：10.1007/s 00429 -014-0763-3）包含补充材料，可供授权用户使用。
Post-mortem studies have shown the maturation of the brain’s myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5 months to 5.5 years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development. The online version of this article (doi:10.1007/s00429-014-0763-3) contains supplementary material, which is available to authorized users.