Are swine workers in the United States at increased risk of infection with zoonotic influenza virus?
Are swine workers in the United States at increased risk of infection with zoonotic influenza virus?
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DOI：
10.1086/498977
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发表时间：
2006-01-01
影响因子：
11.8
通讯作者：
Gray, GC
中科院分区：
文献类型：
--
作者：
Myers, KP;Olsen, CW;Gray, GC
背景大流行性流感病毒株起源于非人类物种。猪在病毒的物种间传播中发挥着重要作用。我们检查了多个猪暴露人群在全国第一的猪生产状态的证据，以前的猪流感病毒感染。我们使用2002-2004年期间收集的血清样本，对111名农民、97名肉类加工工人、65名兽医和79名对照对象进行了对照、横断面血清阳性率研究。使用血凝抑制试验对最近从猪和人中采集的以下6种甲型流感病毒分离株检测血清样本：A/Swine/WI/238/97（H1N1）、A/Swine/ WI/R33F/01（H1N2）、A/Swine/Minnesota/593/99（H3N2）、A/NewCaledonia/20/99（H1N1）、A/Panama/2007/99（H3N2）、和A/Nanchang/933/95（H3 N2）。使用多变量比例优势模型，与对照受试者相比，所有3个暴露研究组均显示出抗H1N1和H1 N2猪流感病毒分离株的滴度显著升高。农民暴露于猪H1N1病毒感染的迹象最强（比值比[OR]，35.3; 95%置信区间[CI]，7.7-161.8），其次是兽医（OR，17.8; 95% CI，3.8-82.7）和肉类加工工人（OR，6.5; 95% CI，1.4-29.5）。同样，农民接触猪H1 N2病毒的几率最高（OR，13.8; 95%CI，5.4 -35.4），其次是兽医（OR，9.5; 95%CI，3.6-24.6）和肉类加工工人（OR，2.7; 95%CI，1.1-6.7）。与猪的职业接触大大增加了工人感染猪流感病毒的风险。
Background. Pandemic influenza strains originate in nonhuman species. Pigs have an important role in interspecies transmission of the virus. We examined multiple swine-exposed human populations in the nation's number 1 swine-producing state for evidence of previous swine influenza virus infection.Methods. We performed controlled, cross-sectional seroprevalence studies among 111 farmers, 97 meat processing workers, 65 veterinarians, and 79 control subjects using serum samples collected during the period of 2002-2004. Serum samples were tested using a hemagglutination inhibition assay against the following 6 influenza A virus isolates collected recently from pigs and humans: A/Swine/WI/238/97 (H1N1), A/Swine/ WI/R33F/01 (H1N2), A/Swine/Minnesota/593/99 (H3N2), A/NewCaledonia/20/99 ( H1N1), A/Panama/2007/99 (H3N2), and A/Nanchang/933/95 (H3N2).Results. Using multivariable proportional odds modeling, all 3 exposed study groups demonstrated markedly elevated titers against the H1N1 and H1N2 swine influenza virus isolates, compared with control subjects. Farmers had the strongest indication of exposure to swine H1N1 virus infection (odds ratio [OR], 35.3; 95% confidence interval [CI], 7.7-161.8), followed by veterinarians ( OR, 17.8; 95% CI, 3.8-82.7), and meat processing workers (OR, 6.5; 95% CI, 1.4-29.5). Similarly, farmers had the highest odds for exposure to swine H1N2 virus ( OR, 13.8; 95% CI,5.4-35.4), followed by veterinarians (OR, 9.5; 95% CI, 3.6-24.6) and meat processing workers (OR, 2.7; 95% CI, 1.1-6.7).Conclusions. Occupational exposure to pigs greatly increases workers' risk of swine influenza virus infection.