Photosensitizer-mediated mitochondria-targeting nanosized drug carriers: Subcellular targeting, therapeutic, and imaging potentials
Photosensitizer-mediated mitochondria-targeting nanosized drug carriers: Subcellular targeting, therapeutic, and imaging potentials
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DOI：
10.1016/j.ijpharm.2017.02.013
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发表时间：
2017-03-30
影响因子：
5.8
通讯作者：
Kang, Han Chang
中科院分区：
文献类型：
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作者：
Choi, Yeon Su;Kwon, Kiyoon;Kang, Han Chang
线粒体靶向药物载体具有相当大的潜力，因为在线粒体中存在许多分子药物靶标，并且它们在细胞活力、代谢、维持和死亡中起关键作用。为了比较三苯基磷（TPP）和脱镁叶绿酸a（PhA）在纳米颗粒（NP）中的线粒体靶向能力，本研究使用甲氧基聚（乙二醇）-（SS-PhA）2 [mPEG-（SS-PhA）2或PPM和TPP-b聚（ε-己内酯）-b-TPP [TPP-b-PCL-b-TPP或TPCL]的混合物制备线粒体靶向NP，其被命名为PPA（n）-TPCL 4-n（0
Mitochondria-targeting drug carriers have considerable potential because of the presence of many molecular drug targets in the mitochondria and their pivotal roles in cellular viability, metabolism, maintenance, and death. To compare the mitochondria-targeting abilities of triphenylphosphonium (TPP) and pheophorbide a (PhA) in nanoparticles (NPs), this study prepared mitochondria -targeting NPs using mixtures of methoxy poly (ethylene glycol)-(SS-PhA)2 [mPEG-(SS-PhA)2 or PPM and TPP-bpoly (epsilon-caprolactone)-b-TPP [TPP-b-PCL-b-TPP or TPCL], which were designated PPA(n)-TPCL4-n (0