PLASTICITY OF HIPPOCAMPAL CIRCUITRY IN ALZHEIMERS-DISEASE
PLASTICITY OF HIPPOCAMPAL CIRCUITRY IN ALZHEIMERS-DISEASE
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DOI：
10.1126/science.4071042
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
CHUI, HC
中科院分区：
文献类型：
--
作者：
GEDDES, JW;MONAGHAN, DT;CHUI, HC
用两种神经元可塑性标志物比较了人类中枢神经系统对阿尔茨海默病引起的神经元丢失的反应与大鼠对病变引起的类似神经元丢失的反应。在接受内嗅皮质损伤的大鼠中，连接纤维和联合纤维的轴突向齿状回的去神经分子层发芽，与氚化kainic酸结合位点分布的扩展相平行。在阿尔茨海默病患者的死后海马样本中观察到类似的kainic酸受体分布的扩大。齿状回分子层乙酰胆碱酯酶活性增强，表明中隔传入发芽，也观察到那些胆碱能神经元损失最小的患者。这些结果证明，中枢神经系统在阿尔茨海默病中具有可塑性反应的能力。适应性生长反应与退行性事件同时发生。
Two markers of neuronal plasticity were used to compare the response of the human central nervous system to neuronal loss resulting from Alzehimer''s disease with the response of rats to a similar neuronal loss induced by lesions. In rats that had received lesions of the entorhinal cortex, axon sprouting of commissural and associational fibers into the denervated molecular layer of the dentate gyrus was paralleled by a spread in the distribution of tritiated kainic acid-binding sites. A similar expansion of kainic acid receptor distribution was observed in hippocampal samples obtained postmortem from patients with Alzheimer''s disease. An enhancement of acetylcholinesterase activity in the dentate gyrus molecular layer, indicative of septal afferent sprouting, was also observed in those patients with a minimal loss of cholinergic neurons. These results are evidence that the central nervous system is capable of a plastic response in Alzheimer''s disease. Adaptive growth responses occur along with the degenerative events.