VARIABILITY IN D-2-DOPAMINE RECEPTOR DENSITY AND AFFINITY - A PET STUDY WITH [C-11] RACLOPRIDE IN MAN
VARIABILITY IN D-2-DOPAMINE RECEPTOR DENSITY AND AFFINITY - A PET STUDY WITH [C-11] RACLOPRIDE IN MAN
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DOI：
10.1002/syn.890200303
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发表时间：
1995-07-01
期刊：
影响因子：
2.3
通讯作者：
HALLDIN, C
中科院分区：
文献类型：
--
作者：
FARDE, L;HALL, H;HALLDIN, C
使用正电子发射断层扫描（PET）和[C-11]雷氯必利测定人体D-2-多巴胺受体结合参数的变异性。在十名男性和十名女性中进行基于五次PET实验的饱和度分析。D-2-多巴胺受体的平均密度（B-max）为28 +/- 6.9 pmol/ml（平均值+/- S.D.）表观亲和力（K-d（app））为9.1 ± 1.9pmol/ml。所有受试者的希尔系数接近1（n（H）：0.999 +/- 0.020），从而表明与同类受体结合。在B-max或K-d（app）中未发现雄性和雌性之间的显著差异。B-max的个体间差异具有统计学显著性（α = 0.01）。K-d（app）差异不显著。受体密度（B-max）的上调已被广泛讨论为精神分裂症中多巴胺能神经传递增加的机制。这项研究表明，受体密度在一组健康受试者中变化很大。(C)1995 Wiley-Liss，Inc.
The variability of D-2-dopamine receptor binding parameters in man was determined using Positron Emission Tomography (PET) and [C-11]raclopride. A saturation analysis based on five PET-experiments was performed in each of ten men and ten women. The mean density of D-2-dopamine receptors (B-max) was 28 +/- 6.9 pmol/ml (mean +/- S.D.) and the apparent affinity (K-d(app)) 9.1 +/- 1.9 pmol/ml. The Hill coefficient was in all subjects close to unity (n(H): 0.999 +/- 0.020), thereby indicating binding to a homogeneous class of receptors. No significant differences between males and females were found in B-max or K-d(app). The interindividual difference in B-max was statistically significant (alpha = 0.01). The difference in K-d(app) was not significant. Upregulation of the receptor density (B-max) has been widely discussed as a mechanism for increased dopaminergic neurotransmission in schizophrenia. This study indicates that receptor density varies considerably in a group of healthy subjects. (C) 1995 Wiley-Liss, Inc.