The NMDA antagonist memantine impairs classical eyeblink conditioning in humans
The NMDA antagonist memantine impairs classical eyeblink conditioning in humans
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DOI：
10.1016/s0304-3940(97)13452-8
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发表时间：
1997-03
影响因子：
2.5
通讯作者：
M. Schugens;Ralf Egerter;I. Daum;K. Schepelmann;T. Klockgether;P. Löschmann
中科院分区：
文献类型：
--
作者：
M. Schugens;Ralf Egerter;I. Daum;K. Schepelmann;T. Klockgether;P. Löschmann
本研究观察了口服单剂量(30 Mg)非竞争性N-甲基-D-天冬氨酸(NMDA)受体拮抗剂美金刚对受试者记忆和学习的影响。16名男性健康志愿者参加了一项双盲安慰剂对照研究。美金刚对情绪、注意力或即刻和延迟的语言和视觉空间记忆没有显著影响。然而，美金刚确实推迟了经典眨眼条件反射的获得，并降低了条件性反应的总体频率，而不影响反射或自发眨眼。这些发现与美金刚与小脑组织相比对小脑的更高亲和力是一致的，并证明了药理学工具对不同记忆系统的可分离性。
The present study investigated the effects of a single oral dose (30 mg) of the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist memantine on memory and learning in human subjects. Sixteen male healthy volunteers participated in a double blind placebo controlled study. There were no significant effects of Memantine on mood, attention or immediate and delayed verbal and visuospatial memory. Memantine did, however, delay the acquisition of classical eyeblink conditioning and reduced the overall frequency of conditioned responses without affecting reflex or spontaneous eyeblinks. These findings are compatible with the higher affinity of memantine to cerebellar as compared to forebrain tissue and demonstrate the dissociability of different memory systems by pharmacological tools.