The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample
The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample
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DOI：
10.1016/j.schres.2010.06.018
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发表时间：
2010-09-01
影响因子：
4.5
通讯作者：
Schulze, Thomas G.
中科院分区：
文献类型：
--
作者：
Nieratschker, Vanessa;Frank, Josef;Schulze, Thomas G.
本研究的目的是探讨精神分裂症与COMT中13个SNP标记之间可能的关联。在631例病例、207个核心家庭和776个对照中没有观察到相关性。一个亚组的患者的认知表现表型（轨迹标记测试）是可用的。未发现13个标记与该表型之间的关联。四个临床定义的亚组（发病年龄早，阴性症状，精神分裂症的家族史，和终身抑郁发作）也进行了调查。在这些亚组中的3个中观察到相关性，尽管没有一个经受住多重检验的校正。COMT似乎不是该人群中精神分裂症的危险因素。(C)2010爱思唯尔有限公司版权所有。
The aim of the present study was to investigate possible associations between schizophrenia and 13 SNP markers in COMT. No association was observed in 631 cases, 207 nuclear families, and 776 controls. A cognitive performance phenotype (Trail Marking Test) was available for a subgroup of the patients. No association was found between the 13 markers and this phenotype. Four clinically-defined subgroups (early age at onset, negative symptoms, family history of schizophrenia, and life-time major depressive episode) were also investigated. Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population. (C) 2010 Elsevier B.V. All rights reserved.