Greater Investments in Safety Net Health Systems Can Help Diversify Participation in Clinical Trials and Research.
Greater Investments in Safety Net Health Systems Can Help Diversify Participation in Clinical Trials and Research.
复制标题
对安全网卫生系统的更多投资可以帮助临床试验和研究的参与多样化。
DOI：
10.1007/s11606-023-08489-6
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发表时间：
2024
影响因子：
5.7
通讯作者：
Neslund-Dudas,Christine
中科院分区：
文献类型：
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作者：
Coronado,GloriaD;Anyane-Yeboa,Adjoa;Byhoff,Elena;Escaron,AnneL;Sonik,Rajan;Talamantes,Efrain;Neslund-Dudas,Christine
美国国家科学、工程和医学院（NASEM; GC是合著者）最近发布的一份报告通过具体的建议以及障碍和促进因素的总结，解决了提高临床试验和研究中代表性不足人群的代表性的紧迫性。研究中缺乏代表性产生的试验结果不能被广泛推广，破坏了对医学研究和公共卫生系统的信任，导致健康结果的差异，并使社会损失数千亿美元。例如，近年来，参加美国国立卫生研究院（NIH）资助的临床试验的西班牙裔人的比例从6.7%到10.8%不等，尽管西班牙裔人占美国人口的19.2%。其他群体也存在差异：美洲印第安人研究参与者在报告所涵盖的5年中的4年中代表性不足，非洲裔美国人研究参与者在5年中的3年中代表性不足。第1、3条
A recently released report from the US National Academies of Sciences, Engineering, and Medicine 1 (NASEM; GC is a co-author) addresses, through specific recommendations as well as a summary of barriers and facilitators, the urgency of improving representation of underrepresented populations in clinical trials and research. Lack of representation in research produces trial findings that cannot be widely generalized, undermines trust in medical research and in our public health system, contributes to disparities in health outcomes, and costs society hundreds of billions of dollars. For example, in recent years, the percentage of Hispanic people enrolled in clinical trials funded by the National Institutes of Health (NIH) has ranged from 6.7 to 10.8%, even though Hispanic people make up 19 2% of the US population. 1, 2 Disparities also exist for other groups: American Indian study participants were underrepresented in 4 of the 5 years covered in the report and African American study participants were underrepresented in 3 of the 5 years. 1, 3