Lipid-lowering treatment is related to decreased risk of dementia: a population-based study (FINRISK).
Lipid-lowering treatment is related to decreased risk of dementia: a population-based study (FINRISK).
复制标题
降脂治疗与降低痴呆风险相关：一项基于人群的研究 (FINRISK)。
DOI：
10.1159/000295659
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Kivipelto,M
中科院分区：
文献类型：
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作者：
Solomon,A;Sippola,R;Soininen,H;Wolozin,B;Tuomilehto,J;Laatikainen,T;Kivipelto,M
背景：有几条证据表明胆固醇与dementions.Objective：探讨降脂药物的使用和痴呆症的发展在芬兰population.Methods：FINRISK是一个大的人口为基础的调查心血管危险因素进行自1972年以来，每5年使用独立的，随机的和代表性的人口样本来自不同地区的芬兰。几个队列是WHO-MONICA研究的一部分。将1972-2002年队列的数据与出院登记处和药物报销登记处（1995-2007年）联系起来，以确定痴呆诊断和降脂治疗。研究的选择标准是：（1）在1995年活着并且没有痴呆;（2）年龄> 60岁（早期队列在1995年，晚期队列在1997年或2002年）;（3）在痴呆诊断前至少1年给予治疗。降脂治疗与痴呆风险降低有关。在考克斯比例风险模型中，风险比（95%CI）为0.42（0.37-0.49;控制年龄，性别，教育，调查地区，调查年份，基线胆固醇，体重指数和收缩压）。结论：FINRISK研究的初步结果表明，降脂药物可能有有益的效果，在痴呆症的预防。进一步的数据链接正在进行中，以研究不同类型的降脂药物的作用。
Background:Several lines of evidence have linked cholesterol to dementia.Objective:To investigate lipid-lowering drug use and dementia development in a Finnish population.Methods:FINRISK is a large population-based survey of cardiovascular risk factors carried out since 1972 every 5 years using independent, random and representative population samples from different parts of Finland. Several cohorts were part of the WHO-MONICA study. Data from cohorts 1972–2002 were linked to the Hospital Discharge Registry and Drug Reimbursement Registry (1995–2007) to ascertain dementia diagnoses and lipid-lowering treatment. Selection criteria for the study were: (1) alive and without dementia in 1995; (2) age ≧60 years (in 1995 for earlier cohorts and in 1997 or 2002 for later cohorts; (3) treatment prescribed at least 1 year before dementia diagnosis.Results:17,597 persons were included in the study. Lipid-lowering treatment was related to decreased dementia risk. In Cox proportional hazards model, hazard ratio (95% CI) was 0.42 (0.37–0.49; controlled for age, sex, education, survey region, survey year, baseline cholesterol, body mass index and systolic blood pressure).Conclusion:Preliminary results from the FINRISK study indicate that lipid-lowering drugs may have a beneficial effect in dementia prevention. Further data linkage is ongoing in order to investigate the roles of different types of lipid-lowering drugs.