Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T
Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T
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DOI：
10.1002/jmri.20729
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发表时间：
2006-11-01
影响因子：
4.4
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Yankeelov, Thomas E.;DeBusk, Laura M.;Gore, John C.
目的：测试参考区域（RR）的重复性。材料和方法：7只小鼠注射106个4 T1乳腺癌细胞，8 - 10天后在Varian 7.0T扫描仪上成像。对每只小鼠进行两次DCE-MRI研究（间隔2.5小时）。用RR模型对数据进行分析，并返回RR和感兴趣组织（TOI）的灌注渗透指数（K-transs）以及TOI的血管外细胞外容积分数（v（e））的估计值。受试者之间高度相关（RR K-transs、TOT K-transs和`TOI v（e）的r（2）分别为0.90、0.62、0.82，所有P均< 0.001）。观察到统计学上的显著变化（在5%水平下）在每组7只动物的治疗研究中，要求肿瘤K-transs和v（e）的log（10）分别为0.084和0.077。如果可靠的动脉输入功能（AIF）不可用，RR模型是在高场下测量癌症小鼠模型中MRI造影剂（CA）动力学的合理替代方案。
Purpose: To test the repeatability of a reference region (RR.) model for the analysis of dynamic contrast-enhanced MRI (DCE-MRI) in a mouse model of cancer at high field.Materials and Methods: Seven mice were injected with 106 4T1 mammary carcinoma cells and imaged eight to 10 days later on a Varian 7.0T scanner. Two DCE-MRI studies were performed for each mouse (separated by 2.5 hours). The RR model was,used to, analyze the data, and, returned estimates on the perfusion-permeability index (K-trans) for the RR and the tissue of interest (TOI), as well as the extravascular extracellular volume fraction (v(e)) for the TOI.Results: Whent he first injection,Was compared with the second injectiori, all baxameters. tested were highly correlated (r(2) = 0.90, 0.62, 0.82 for the RR K-trans, TOT K-trans, and`TOI v(e), respectively, with P < 0.001 for all). To observe a statistically significant change (at the 5%-level) in a treatment study with 1 seven animals in each group log(10) chapges,of 0.084 and 0.077 in the tumor K-trans and v(e), respectively, are required Conclusion: If a reliable arterial input function (AIF) is unavailable, the RR model is a reasonable alternative to measuring MRI contrast-agent (CA) kinetics in mouse models of cancer at high field.