Potential of Electrical Neuromodulation for Inflammatory Bowel Disease
Potential of Electrical Neuromodulation for Inflammatory Bowel Disease
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DOI：
10.1093/ibd/izz289
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发表时间：
2020-08-01
影响因子：
4.9
通讯作者：
Chen, Jiande D. Z.
中科院分区：
文献类型：
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作者：
Cheng, Jiafei;Shen, Hong;Chen, Jiande D. Z.
炎症性肠病 (IBD) 是一种常见的消化道慢性炎症性疾病，常常使人衰弱。它影响患者的生活质量并造成经济负担。尽管生物制剂等药物治疗取得了进展，但很大一部分患者对药物治疗没有反应或出现不良事件。因此，目前正在研究替代治疗方案，例如电神经调节。电神经调节，也称为生物电子医学，正在成为 IBD 的潜在新疗法。在过去的十年中，电神经调节领域取得了进步。许多电神经调节方法，如迷走神经刺激、骶神经刺激和胫神经刺激，已被测试用于治疗 IBD。已经进行了一系列动物和临床试验来评估疗效并取得了有希望的结果。尽管电神经调节的确切潜在作用机制仍有待探索，但这种方式很有希望。需要进一步的随机对照试验和基础实验来研究疗效并阐明内在机制。
Inflammatory bowel disease (IBD) is a common chronic inflammatory disease of the digestive tract that is often debilitating. It affects patients' quality of life and imposes a financial burden. Despite advances in treatment with medications such as biologics, a large proportion of patients do not respond to medical therapy or develop adverse events. Therefore, alternative treatment options such as electrical neuromodulation are currently being investigated. Electrical neuromodulation, also called bioelectronic medicine, is emerging as a potential new treatment for IBD. Over the past decade, advancements have been made in electrical neuromodulation. A number of electrical neuromodulation methods, such as vagus nerve stimulation, sacral nerve stimulation, and tibial nerve stimulation, have been tested to treat IBD. A series of animal and clinical trials have been performed to evaluate efficacy with promising results. Although the exact underlying mechanisms of action for electrical neuromodulation remain to be explored, this modality is promising. Further randomized controlled trials and basic experiments are needed to investigate efficacy and clarify intrinsic mechanisms.