LONG-TERM HABITUATION OF A DEFENSIVE WITHDRAWAL REFLEX IN APLYSIA
LONG-TERM HABITUATION OF A DEFENSIVE WITHDRAWAL REFLEX IN APLYSIA
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DOI：
10.1126/science.175.4020.451
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发表时间：
1972-01-01
期刊：
影响因子：
56.9
通讯作者：
KANDEL, ER
中科院分区：
文献类型：
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作者：
CAREW, TJ;PINSKER, HM;KANDEL, ER
触觉刺激的虹吸管的Aaprosiaproduces一个防御性撤回反射包括收缩的虹吸管，鳃，和外套架。我们研究了长期习惯化的这种反射使用两种类型的制剂，一个专注于虹吸组件和其他鳃组件的反射。在不受限制的动物中进行的虹吸管撤回研究表明，在一个单一的10次试验训练期间内出现了明显的习惯性。每天五次训练会产生习惯，这些习惯会在几天内建立起来，并持续至少3周。此外，间隔训练比集中训练产生更持久的习惯。在受约束的动物中研究的鳃退缩也显示出长期的习惯性保留。由于鳃撤回的神经回路是相对较好的理解，它可能是一个长期的行为改变的细胞机制进行研究。
A tactile stimulus to the siphon ofAplysiaproduces a defensive withdrawal reflex consisting of contraction of the siphon, the gill, and the mantle shelf. We studied long-term habituation of this reflex using two types of preparations, one focusing on the siphon component and the other on the gill component of the reflex. Siphon withdrawal, studied in unrestrained animals, showed marked habituation within a single ten-trial training session. Five daily training sessions produced habituaton that built up across days and lasted for at least 3 weeks. Furthermore, spaced training produced significantly longer lasting habituation than massed training. Gill withdrawal, studied in a restrained animal, also showed long-term retention of habituation. Since the neural circuitry of gill withdrawal is relatively well understood, it may be possible to study the cellular mechanisms underlying a long-term behavioral modification.