Factors that influence health-related quality of life in Australian adults with Charcot-Marie-Tooth disease
Factors that influence health-related quality of life in Australian adults with Charcot-Marie-Tooth disease
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DOI：
10.1016/j.nmd.2008.05.015
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发表时间：
2008-08-01
影响因子：
2.8
通讯作者：
Ouvrier, Robert A.
中科院分区：
文献类型：
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作者：
Redmond, Anthony C.;Burns, Joshua;Ouvrier, Robert A.
与健康有关的。生活质量（HRQoL）是腓骨肌痛（CMT）患者临床试验的重要结果。在一项对295名患有CMT的澳大利亚成年人的横断面调查中，使用简短表格36 （SF-36）测量HRQoL，并通过CMT特异性健康状况问卷确定HRQoL降低的预测因子。在SF-36的所有维度上，CMT患者的HRQoL得分低于澳大利亚普通人群。CMT患者与标准数据之间的差异在生理维度上大于心理健康维度。SF-36得分在老年人中普遍低于年轻人，但在男性和女性之间，或在CMT类型之间则没有。下肢无力对CMT患者的HRQoL有很强的预测作用，腿部抽筋对HRQoL的预测作用较小，提示针对下肢无力和腿部抽筋的临床试验可能改善CMT患者的HRQoL。(C) 2008 Elsevier B.V.版权所有
Health-related. quality of life (HRQoL) is in important outcome in clinical trials of patients with Charcot-Marie-Tooth disease (CMT). In a cross-sectional survey of 295 Australian adults with CMT, HRQoL was measured using the Short Form-36 (SF-36) and predictors of reduced HRQoL were identified with a CMT-specific health status questionnaire. People with CMT demonstrated lower HRQoL scores than the general Australian population in all SF-36 dimensions. The disparity between people with CMT and normative data was greater for physical dimensions than for mental health dimensions. SF-36 scores were generally lower in older vs younger people, but not between men and women, or between CMT types. HRQoL in CMT was predicted strongly by lower limb weakness and to a lessor extent by leg cramps, suggesting clinical trials targeting weakness and cramps may improve HRQoL in patients with CMT. (C) 2008 Elsevier B.V. All rights reserved.