Prefrontal-amygdala fear networks come into focus.
Prefrontal-amygdala fear networks come into focus.
复制标题
DOI：
10.3389/fnsys.2015.00145
复制
发表时间：
2015
影响因子：
3
通讯作者：
Clem RL
中科院分区：
文献类型：
--
作者：
Arruda-Carvalho M;Clem RL
在令人厌恶的威胁和它们的预测者之间形成联系的能力是生存的基础。然而，过度的恐惧和焦虑是有害的，是创伤后应激障碍（PTSD）等精神疾病的标志。创伤后应激障碍的症状包括对经历过的创伤的持续和侵入性的想法，表明当相应的威胁消退时无法下调恐惧。来自人类和啮齿动物研究的趋同证据支持内侧前额叶皮层(mPFC)-杏仁核网络在创伤后应激障碍和恐惧记忆表达调节中的作用。特别是，目前的模型表明，啮齿动物mPFC的边缘前（PL）和边缘下（IL）分支通过杏仁核神经元亚群的差异募集双向调节恐惧表达。然而，最近一系列采用新技术方法的研究从根本上挑战了这种解释。在这里，我们探讨了抑制性神经元群、皮层下结构和时间流逝的新重点如何重塑我们对mpfc -杏仁核回路及其对恐惧的控制的理解。
The ability to form associations between aversive threats and their predictors is fundamental to survival. However, fear and anxiety in excess are detrimental and are a hallmark of psychiatric diseases such as post-traumatic stress disorder (PTSD). PTSD symptomatology includes persistent and intrusive thoughts of an experienced trauma, suggesting an inability to downregulate fear when a corresponding threat has subsided. Convergent evidence from human and rodent studies supports a role for the medial prefrontal cortex (mPFC)-amygdala network in both PTSD and the regulation of fear memory expression. In particular, current models stipulate that the prelimbic (PL) and infralimbic (IL) subdivisions of the rodent mPFC bidirectionally regulate fear expression via differential recruitment of amygdala neuronal subpopulations. However, an array of recent studies that employ new technical approaches has fundamentally challenged this interpretation. Here we explore how a new emphasis on the contribution of inhibitory neuronal populations, subcortical structures and the passage of time is reshaping our understanding of mPFC-amygdala circuits and their control over fear.