SNF5 as a prognostic factor in skull base chordoma
SNF5 as a prognostic factor in skull base chordoma
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DOI：
10.1007/s11060-017-2706-3
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发表时间：
2018-03-01
影响因子：
3.9
通讯作者：
Zhang, Yazhuo
中科院分区：
文献类型：
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作者：
Li, Mingxuan;Zhai, Yixuan;Zhang, Yazhuo
本研究旨在表征 SNF5 表达特征并探讨 SNF5 与颅底脊索瘤临床病理特征之间的关系。 48 名诊断为颅底脊索瘤的患者参加了这项研究。采用组织微阵列和免疫组织化学方法评估颅底脊索瘤中 SNF5 的表达。 Kaplan-Meier 生存分析用于评估生存。使用多变量Cox回归分析来确定影响患者生存的危险因素。细胞质 SNF5 的 H 分数范围为 124.47 至 254.52。 SNF5 的低表达与较短的总生存期 (OS) 相关 (p = 0.021)。年龄 > 55 岁的患者比年龄 55 岁的患者具有更短的无进展生存期 (PFS) 和 OS 时间（分别为 p = 0.005 和 0.003）。肉眼全切除组的 PFS 比非肉眼全切除组更长 (p = 0.024)。女性的 PFS 时间短于男性 (p = 0.033)。多变量 Cox 回归分析显示，年龄、切除范围和性别是 PFS 的独立预后因素（分别为 p = 0.010、0.013 和 0.042）。年龄是 OS 的独立预后因素 (p = 0.010)。我们的研究表明 SNF5 的低表达与颅底脊索瘤的不良预后相关。
The current study aimed to characterize SNF5 expression and investigate the relationship between SNF5 and clinicopathological features in skull base chordoma. 48 patients diagnosed with skull base chordoma were enrolled in this study. Tissue microarray and immunohistochemistry were performed to evaluate the expression of SNF5 in skull base chordoma. Kaplan-Meier survival analysis was used to assess survival. Multivariable Cox regression analysis was used to identify risk factors affecting patient survival. The H-scores for cytoplasmic SNF5 ranged from 124.47 to 254.52. Low expression of SNF5 was correlated with shorter overall survival (OS) (p = 0.021). Patients with age > 55 years old had shorter progression free survival (PFS) and OS times than patients whose age ae 55 years old (p = 0.005 and 0.003, respectively). The gross total resection group showed longer PFS than the non-gross total resection group (p = 0.024). Females showed shorter PFS times than males (p = 0.033). Multivariable Cox regression analysis showed that age, extent of resection and sex were independent prognostic factors for PFS (p = 0.010, 0.013 and 0.042, respectively). Age was an independent prognostic factor for OS (p = 0.010). Our study indicate that low expression of SNF5 is associated with poor prognosis in skull base chordoma.