INDOLE(ETHYL)AMINE N-METHYLTRANSFERASE IN BRAIN

INDOLE(ETHYL)AMINE N-METHYLTRANSFERASE IN BRAIN
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DOI：
10.1126/science.165.3892.492
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发表时间：
1969-01-01
期刊：
SCIENCE
影响因子：
56.9
通讯作者：
MANDELL, AJ
MANDELL, AJ
中科院分区：
综合性期刊1区
文献类型：
--
作者：
MORGAN, M;MANDELL, AJ

文献摘要

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从脑垂体和松果体中分离出一种能N-甲基化各种吲哚（乙基）胺底物的酶。在不连续蔗糖梯度离心后，它出现定位于上清液和突触体区域。这是第一次证明大脑中的酶。
An enzyme whichN-methylates various indole(ethyl)amine substrates was isolated from brain, separated from the pituitary and the pineal glands. It appeared localized in the supernatant and synaptosomal areas after discontinuous sucrose-gradient ultracentrifugation. This is the first demonstration of the enzyme in brain.