Sequence, stability, and structure of G-quadruplexes and their interactions with drugs.
Sequence, stability, and structure of G-quadruplexes and their interactions with drugs.
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DOI：
10.1002/0471142700.nc1705s50
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发表时间：
2012-09
影响因子：
--
通讯作者：
Yang, Danzhou
中科院分区：
文献类型：
--
作者：
Chen, Yuwei;Yang, Danzhou
虽然DNA最广为人知的功能是存储和传递遗传信息，但G-四链结构的发现揭示了DNA在生物学中的新角色。DNA G-四联体是在特定的富含G的序列中形成的具有生物学意义的四链球状核酸二级结构，如人类端粒和癌基因启动子。本文综述了单分子DNA G-四链体，它在生理条件下很容易在溶液中形成，被认为是最具生物学意义的。现有的结构数据表明，单分子G-四联体具有很大的构象多样性，适合于小分子药物靶向。将讨论单分子DNA G-四链的序列、结构和稳定性的关系，以及与小分子化合物相互作用的最新进展和对G-四链相互作用分子的合理设计的见解。
Although DNA is most widely known to store and pass along genetic information, the discovery of G-quadruplex structures has illuminated a new role of DNA in biology. DNA G-quadruplexes are four-stranded globular nucleic acid secondary structures formed in specific G-rich sequences with biological significance, such as human telomeres and oncogene promoters. This review focuses on the unimolecular DNA G-quadruplexes, which can readily form in solution under physiological conditions and are considered to be most biologically relevant. Available structural data show a great conformational diversity of unimolecular G-quadruplexes, amenable to small molecule drug targeting. The relationship of sequence, structure, and stability of unimolecular DNA G-quadruplexes, as well as the recent progress on interactions with small molecule compounds and insights into rational design of G-quadruplex-interactive molecules, will be discussed.